PDB entry 3sp8

View 3sp8 on RCSB PDB site
Description: Crystal structure of NK2 in complex with fractionated Heparin DP10
Class: hormone
Keywords: kringle domain, MET Tyrosine Kinase, HORMONE
Deposited on 2011-07-01, released 2012-07-04
The last revision prior to the SCOPe 2.06 freeze date was dated 2012-07-04, with a file datestamp of 2012-06-29.
Experiment type: XRAY
Resolution: 1.86 Å
R-factor: 0.188
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Hepatocyte growth factor alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HGF, HPTA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14210 (Start-262)
      • engineered mutation (120)
      • engineered mutation (188)
      • conflict (258)
      • expression tag (263)
    Domains in SCOPe 2.06: d3sp8a1, d3sp8a2, d3sp8a3, d3sp8a4
  • Chain 'B':
    Compound: Hepatocyte growth factor alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HGF, HPTA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14210 (Start-262)
      • engineered mutation (120)
      • engineered mutation (188)
      • conflict (258)
      • expression tag (263)
    Domains in SCOPe 2.06: d3sp8b1, d3sp8b2, d3sp8b3, d3sp8b4
  • Heterogens: MRD, MES, MPD, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3sp8A (A:)
gsyaegqrkrrntihefkksakttlikidpalkiktkkvntadqcanrctrnkglpftck
afvfdkarkqclwfpfnsmssgvkkefghefdlyenkdyirnciigkgrsykgtvsitks
dikcqpwssmiphehsflpssyrgkdlqenycrnprgeeggpwcftsnpevryevcdipq
csevecmtsngesyrglmdhtesgkicqrwdhqtphrhkflperypdkgfddnycrnpdg
qprpwcytldphtrweyckiktck

    Sequence, based on observed residues (ATOM records): (download) 
    >3sp8A (A:)
rrntihefkksakttlikidpalkiktkkvntadqcanrctrnkglpftckafvfdkark
qclwfpfnsmssgvkkefghefdlyenkdyirnciigkgrsykgtvsitksdikcqpwss
miphehsflpssyrgkdlqenycrnprgeeggpwcftsnpevryevcdipqcsevecmts
ngesyrglmdhtesgkicqrwdhqtphrhkflperypdkgfddnycrnpdgqprpwcytl
dphtrweyckiktck

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3sp8B (B:)
gsyaegqrkrrntihefkksakttlikidpalkiktkkvntadqcanrctrnkglpftck
afvfdkarkqclwfpfnsmssgvkkefghefdlyenkdyirnciigkgrsykgtvsitks
dikcqpwssmiphehsflpssyrgkdlqenycrnprgeeggpwcftsnpevryevcdipq
csevecmtsngesyrglmdhtesgkicqrwdhqtphrhkflperypdkgfddnycrnpdg
qprpwcytldphtrweyckiktck

    Sequence, based on observed residues (ATOM records): (download) 
    >3sp8B (B:)
krrntihefkksakttlikidpalkiktkkvntadqcanrctrnkglpftckafvfdkar
kqclwfpfnsmssgvkkefghefdlyenkdyirnciigkgrsykgtvsitksdikcqpws
smiphehsflpssyrgkdlqenycrnprgeeggpwcftsnpevryevcdipqcsevecmt
sngesyrglmdhtesgkicqrwdhqtphrhkflperypdkgfddnycrnpdgqprpwcyt
ldphtrweyckiktck