PDB entry 3soc

View 3soc on RCSB PDB site
Description: Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with a quinazolin
Class: transferase
Keywords: Structural Genomics Consortium, SGC, TRANSFERASE, Protein kinase
Deposited on 2011-06-30, released 2011-07-20
The last revision prior to the SCOPe 2.03 freeze date was dated 2011-07-20, with a file datestamp of 2011-07-15.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: 0.165
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Activin receptor type-2A
    Species: Homo sapiens [TaxId:9606]
    Gene: ACVR2, ACVR2A
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27037 (24-End)
      • expression tag (13-23)
    Domains in SCOPe 2.03: d3soca_
  • Chain 'B':
    Compound: Activin receptor type-2A
    Species: Homo sapiens [TaxId:9606]
    Gene: ACVR2, ACVR2A
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27037 (24-End)
      • expression tag (9-23)
    Domains in SCOPe 2.03: d3socb_
  • Heterogens: GVD, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3socA (A:)
mghhhhhhssgvdlgtenlyfqsmplqllevkargrfgcvwkaqllneyvavkifpiqdk
qswqneyevyslpgmkhenilqfigaekrgtsvdvdlwlitafhekgslsdflkanvvsw
nelchiaetmarglaylhedipglkdghkpaishrdiksknvllknnltaciadfglalk
feagksagdthgqvgtrrymapevlegainfqrdaflridmyamglvlwelasrctaadg
pvdeymlpfeeeigqhpsledmqevvvhkkkrpvlrdywqkhagmamlcetieecwdhda
earlsagcvgeritqmqrltni

    Sequence, based on observed residues (ATOM records): (download) 
    >3socA (A:)
lgtenlyfqsmplqllevkargrfgcvwkaqllneyvavkifpiqdkqswqneyevyslp
gmkhenilqfigaekrgtsvdvdlwlitafhekgslsdflkanvvswnelchiaetmarg
laylhedipglkdghkpaishrdiksknvllknnltaciadfglalkfeagksagdthgq
vgtrrymapevlegainfqrdaflridmyamglvlwelasrctaadgpvdeymlpfeeei
gqhpsledmqevvvhkkkrpvlrdywqkhagmamlcetieecwdhdaearlsagcvgeri
tqmqrlt

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3socB (B:)
mghhhhhhssgvdlgtenlyfqsmplqllevkargrfgcvwkaqllneyvavkifpiqdk
qswqneyevyslpgmkhenilqfigaekrgtsvdvdlwlitafhekgslsdflkanvvsw
nelchiaetmarglaylhedipglkdghkpaishrdiksknvllknnltaciadfglalk
feagksagdthgqvgtrrymapevlegainfqrdaflridmyamglvlwelasrctaadg
pvdeymlpfeeeigqhpsledmqevvvhkkkrpvlrdywqkhagmamlcetieecwdhda
earlsagcvgeritqmqrltni

    Sequence, based on observed residues (ATOM records): (download) 
    >3socB (B:)
sgvdlgtenlyfqsmplqllevkargrfgcvwkaqllneyvavkifpiqdkqswqneyev
yslpgmkhenilqfigaekrgtsvdvdlwlitafhekgslsdflkanvvswnelchiaet
marglaylhedipglkdghkpaishrdiksknvllknnltaciadfglalkfeagksath
gqvgtrrymapevlegainfqrdaflridmyamglvlwelasrctaadgpvdeymlpfee
eigqhpsledmqevvvhkkkrpvlrdywqkhagmamlcetieecwdhdaearlsagcvge
ritqmqrlt