PDB entry 3sin

View 3sin on RCSB PDB site
Description: Crystal Strucutre of N10-Formyltetrahydrofolate Synthetase with ZD9331 and Formylphosphate
Class: ligase/ligase inhibitor
Keywords: Ligase, LIGASE-LIGASE INHIBITOR complex
Deposited on 2011-06-19, released 2011-12-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-03-20, with a file datestamp of 2013-03-15.
Experiment type: XRAY
Resolution: 2.67 Å
R-factor: 0.205
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Formate--tetrahydrofolate ligase
    Species: Moorella thermoacetica [TaxId:1525]
    Gene: fhs, Moorella
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3sina_
  • Chain 'B':
    Compound: Formate--tetrahydrofolate ligase
    Species: Moorella thermoacetica [TaxId:1525]
    Gene: fhs, Moorella
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3sinb_
  • Heterogens: ZD9, XPO, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3sinA (A:)
mskvpsdieiaqaakmkpvmelarglgiqedevelygkykakisldvyrrlkdkpdgkli
lvtaitptpagegktttsvgltdalarlgkrvmvclrepslgpsfgikggaagggyaqvv
pmedinlhftgdihavtyahnllaamvdnhlqqgnvlnidprtitwrrvidlndralrni
viglggkangvpretgfdisvasevmaclclasdlmdlkerfsrivvgytydgkpvtagd
leaqgsmallmkdaikpnlvqtlentpafihggpfaniahgcnsiiatktalkladyvvt
eagfgadlgaekfydvkcryagfkpdatvivatvralkmhggvpksdlatenlealregf
anlekhienigkfgvpavvainafptdteaelnllyelcakagaevalswakggegglel
arkvlqtlesrpsnfhvlynldlsikdkiakiateiygadgvnytaeadkaiqryeslgy
gnlpvvmaktqysfsddmtklgrprnftitvrevrlsaggrlivpitgaimtmpglpkrp
aacnididadgvitglf

    Sequence, based on observed residues (ATOM records): (download) 
    >3sinA (A:)
psdieiaqaakmkpvmelarglgiqedevelygkykakisldvyrrlkdkpdgklilvta
itptpagegktttsvgltdalarlgkrvmvclrepslgpsfgikggaagggyaqvvpmed
inlhftgdihavtyahnllaamvdnhlqqgnvlnidprtitwrrvidlndralrnivigl
ggkangvpretgfdisvasevmaclclasdlmdlkerfsrivvgytydgkpvtagdleaq
gsmallmkdaikpnlvqtlentpafihggpfaniahgcnsiiatktalkladyvvteagf
gadlgaekfydvkcryagfkpdatvivatvralkmhggvpksdlatenlealregfanle
khienigkfgvpavvainafptdteaelnllyelcakagaevalswakggegglelarkv
lqtlesrpsnfhvlynldlsikdkiakiateiygadgvnytaeadkaiqryeslgygnlp
vvmaktqysfsddmtklgrprnftitvrevrlsaggrlivpitgaimtmpglpkrpaacn
ididadgvitg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3sinB (B:)
mskvpsdieiaqaakmkpvmelarglgiqedevelygkykakisldvyrrlkdkpdgkli
lvtaitptpagegktttsvgltdalarlgkrvmvclrepslgpsfgikggaagggyaqvv
pmedinlhftgdihavtyahnllaamvdnhlqqgnvlnidprtitwrrvidlndralrni
viglggkangvpretgfdisvasevmaclclasdlmdlkerfsrivvgytydgkpvtagd
leaqgsmallmkdaikpnlvqtlentpafihggpfaniahgcnsiiatktalkladyvvt
eagfgadlgaekfydvkcryagfkpdatvivatvralkmhggvpksdlatenlealregf
anlekhienigkfgvpavvainafptdteaelnllyelcakagaevalswakggegglel
arkvlqtlesrpsnfhvlynldlsikdkiakiateiygadgvnytaeadkaiqryeslgy
gnlpvvmaktqysfsddmtklgrprnftitvrevrlsaggrlivpitgaimtmpglpkrp
aacnididadgvitglf

    Sequence, based on observed residues (ATOM records): (download) 
    >3sinB (B:)
dieiaqaakmkpvmelarglgiqedevelygkykakisldvyrrlkdkpdgklilvtait
ptpagegktttsvgltdalarlgkrvmvclrepslgpsfgikggaagggyaqvvpmedin
lhftgdihavtyahnllaamvdnhlqqgnvlnidprtitwrrvidlndralrniviglgg
kangvpretgfdisvasevmaclclasdlmdlkerfsrivvgytydgkpvtagdleaqgs
mallmkdaikpnlvqtlentpafihggpfaniahgcnsiiatktalkladyvvteagfga
dlgaekfydvkcryagfkpdatvivatvralkmhggvpksdlatenlealregfanlekh
ienigkfgvpavvainafptdteaelnllyelcakagaevalswakggegglelarkvlq
tlesrpsnfhvlynldlsikdkiakiateiygadgvnytaeadkaiqryeslgygnlpvv
maktqysfsddmtklgrprnftitvrevrlsaggrlivpitgaimtmpglpkrpaacnid
idadgvitgl