PDB entry 3s5e

View 3s5e on RCSB PDB site
Description: Crystal structure of human frataxin variant W155R, one of the Friedreich's ataxia point mutations
Class: unknown function
Keywords: allosteric activator, mitochondrion, alpha beta 2-layer sandwich, UNKNOWN FUNCTION
Deposited on 2011-05-23, released 2011-06-29
The last revision prior to the SCOPe 2.03 freeze date was dated 2011-08-03, with a file datestamp of 2011-07-29.
Experiment type: XRAY
Resolution: 1.31 Å
R-factor: 0.153
AEROSPACI score: 0.76 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Frataxin, mitochondrial
    Species: Homo sapiens [TaxId:9606]
    Gene: FRDA, FXN, X25
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16595
      • engineered mutation (73)
    Domains in SCOPe 2.03: d3s5ea_
  • Heterogens: MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3s5eA (A:)
gtlghpgsldettyerlaeetldslaeffedladkpytfedydvsfgsgvltvklggdlg
tyvinkqtpnkqirlsspssgpkrydwtgknwvyshdgvslhellaaeltkalktkldls
slaysgkda

    Sequence, based on observed residues (ATOM records): (download) 
    >3s5eA (A:)
gsldettyerlaeetldslaeffedladkpytfedydvsfgsgvltvklggdlgtyvink
qtpnkqirlsspssgpkrydwtgknwvyshdgvslhellaaeltkalktkldlsslaysg
k