PDB entry 3rx3

View 3rx3 on RCSB PDB site
Description: Crystal Structure of Human Aldose Reductase Complexed with Sulindac
Class: oxidoreductase
Keywords: Aldose Reductase, OXIDOREDUCTASE
Deposited on 2011-05-10, released 2011-11-30
The last revision prior to the SCOPe 2.04 freeze date was dated 2013-07-03, with a file datestamp of 2013-06-28.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.153
AEROSPACI score: 0.53 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: aldose reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: AKR1B1, ALDR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P15121 (20-335)
      • expression tag (18-19)
    Domains in SCOPe 2.04: d3rx3a_
  • Heterogens: NAP, SUZ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3rx3A (A:)
mgsshhhhhhssglvprgshmasrlllnngakmpilglgtwksppgqvteavkvaidvgy
rhidcahvyqnenevgvaiqeklreqvvkreelfivsklwctyhekglvkgacqktlsdl
kldyldlylihwptgfkpgkeffpldesgnvvpsdtnildtwaameelvdeglvkaigis
nfnhlqvemilnkpglkykpavnqiechpyltqekliqycqskgivvtaysplgspdrpw
akpedpslledprikaiaakhnkttaqvlirfpmqrnlvvipksvtperiaenfkvfdfe
lssqdmttllsynrnwrvcallsctshkdypfheef

    Sequence, based on observed residues (ATOM records): (download) 
    >3rx3A (A:)
shmasrlllnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgva
iqeklreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwptgfkp
gkeffpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglky
kpavnqiechpyltqekliqycqskgivvtaysplgspdrpwakpedpslledprikaia
akhnkttaqvlirfpmqrnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwrv
callsctshkdypfheef