PDB entry 3rc6

View 3rc6 on RCSB PDB site
Description: Molecular mechanisms of viral and host-cell substrate recognition by HCV NS3/4A protease
Class: viral protein, hydrolase
Keywords: drug resistance, drug design, Protease inhibitors, serine protease, VIRAL PROTEIN, HYDROLASE
Deposited on 2011-03-30, released 2011-05-04
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-08, with a file datestamp of 2017-11-03.
Experiment type: XRAY
Resolution: 1.3 Å
R-factor: N/A
AEROSPACI score: 0.58 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: ns3/4a
  Species: Hepatitis C virus subtype 1a [TaxId:31646]
  Gene: NS3
  Database cross-references and differences (RAF-indexed):
  • Uniprot A8DG50 (10-20)
    • expression tag (0-5)
    • engineered mutation (6-9)
    • see remark 999 (11)
    • see remark 999 (18-19)
  • Uniprot A8DG50 (21-End)
    • engineered mutation (21-23)
    • engineered mutation (33-34)
    • engineered mutation (37-38)
    • engineered mutation (41)
    • engineered mutation (60)
    • engineered mutation (67)
    • engineered mutation (72)
    • engineered mutation (92)
    • engineered mutation (106)
    • engineered mutation (159)
    • engineered mutation (179)
  Domains in SCOPe 2.07: d3rc6a1, d3rc6a2
• Heterogens: ZN, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence, based on SEQRES records: (download)
  

  >3rc6A (A:)
  gshmasmkkkgsvvivgrinlsgdtayaqqtrgeegcqetsqtgrdknqvegevqivsta
  tqtflatsingvlwtvyhgagtrtiaspkgpvtqmytnvdkdlvgwqapqgsrsltpctc
  gssdlylvtrhadvipvrrrgdsrgsllsprpisylkgsaggpllcpaghavgifraavs
  trgvakavdfipveslettmrsp
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >3rc6A (A:)
  gshmasmkkkgsvvivgrinlsgdtayaqqtrgeegcqetsqtgrdknqvegevqivsta
  tqtflatsingvlwtvyhgagtrtiaspkgpvtqmytnvdkdlvgwqapqgsrsltpctc
  gssdlylvtrhadvipvrrrgdsrgsllsprpisylkgsaggpllcpaghavgifraavs
  trgvakavdfipveslettmrs