PDB entry 3oxi

View 3oxi on RCSB PDB site
Description: Design and Synthesis of Disubstituted Thiophene and Thiazole Based Inhibitors of JNK for the Treatment of Neurodegenerative Diseases
Class: transferase/transferase inhibitor
Keywords: JNK inhibitors, Neurodegenerative Diseases, kinase, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2010-09-21, released 2011-05-04
The last revision prior to the SCOPe 2.04 freeze date was dated 2012-02-29, with a file datestamp of 2012-02-24.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.232
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Mitogen-activated protein kinase 10
    Species: Homo sapiens [TaxId:9606]
    Gene: JNK3, JNK3A, MAPK10, PRKM10
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3oxia_
  • Chain 'J':
    Compound: Mitogen-activated protein kinase 8 interacting protein 1
    Species: Homo sapiens [TaxId:9606]
    Gene: MAPK8IP1
    Database cross-references and differences (RAF-indexed):
  • Heterogens: SYY, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3oxiA (A:)
skskvdnqfysvevgdstftvlkryqnlkpigsgaqgivcaaydavldrnvaikklsrpf
qnqthakrayrelvlmkcvnhkniisllnvftpqktleefqdvylvmelmdanlcqviqm
eldhermsyllyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfglartagtsfm
mtpyvvtryyrapevilgmgykenvdiwsvgcimgemvrhkilfpgrdyidqwnkvieql
gtpcpefmkklqptvrnyvenrpkyagltfpklfpdslfpadsehnklkasqardllskm
lvidpakrisvddalqhpyinvwydpaeveapppqiydkqlderehtieewkeliykevm
ns

    Sequence, based on observed residues (ATOM records): (download) 
    >3oxiA (A:)
nqfysvevgdstftvlkryqnlkpigsgaqgivcaaydavldrnvaikklsrpfqnqtha
krayrelvlmkcvnhkniisllnvftpqktleefqdvylvmelmdanlcqviqmeldher
msyllyqmlcgikhlhsagiihrdlkpsnivvksdctlkildfgvtryyrapevilgmgy
kenvdiwsvgcimgemvrhkilfpgrdyidqwnkvieqlgtpcpefmkklqptvrnyven
rpkyagltfpklfpdslfphnklkasqardllskmlvidpakrisvddalqhpyinvwyd
paevrehtieewkeliykevmn

  • Chain 'J':
    No sequence available.