PDB entry 3onc
View 3onc on RCSB PDB site
Description: Bond breakage and relocation of a covalently bound bromine of IDD594 in a complex with hAR T113A mutant after moderate radiation dose
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: radiation damage, T113A mutant, TIM barrel, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Deposited on
2010-08-28, released
2011-08-17
The last revision prior to the SCOPe 2.04 freeze date was dated
2011-11-02, with a file datestamp of
2011-10-28.
Experiment type: XRAY
Resolution: 1.06 Å
R-factor: 0.096
AEROSPACI score: 1.02
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: aldose reductase
Species: Homo sapiens [TaxId:9606]
Gene: ALR2
Database cross-references and differences (RAF-indexed):
- Uniprot P15121 (0-End)
- see remark 999 (3)
- engineered mutation (112)
Domains in SCOPe 2.04: d3onca_ - Heterogens: NAP, LDT, BR, CIT, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3oncA (A:)
asrillnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgvaiqe
klreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwpagfkpgke
ffpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglkykpa
vnqiechpyltqekliqycqskgivvtaysplgspdrpwakpedpslledprikaiaakh
nkttaqvlirfpmqrnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwrvcal
lsctshkdypfheef
Sequence, based on observed residues (ATOM records): (download)
>3oncA (A:)
asrillnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgvaiqe
klreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwpagfkpgke
ffpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglkykpa
vnqiechpyltqekliqycqskgivvtaysplgspdrpwakpedpslledprikaiaakh
nkttaqvlirfpmqrnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwrvcal
lsctshkdypfhe