PDB entry 3nxu

View 3nxu on RCSB PDB site
Description: Crystal structure of human cytochrome P4503A4 bound to an inhibitor ritonavir
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: alpha beta protein, cytochrome P450 fold, hemoprotein, monooxygenase, cytochrome P450 reductase, endoplasmic reticulum, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Deposited on 2010-07-14, released 2010-10-20
The last revision prior to the SCOPe 2.02 freeze date was dated 2010-12-22, with a file datestamp of 2010-12-17.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.232
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cytochrome p450 3a4
    Species: Homo sapiens [TaxId:9606]
    Gene: CYP3A3, CYP3A4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d3nxua_
  • Chain 'B':
    Compound: cytochrome p450 3a4
    Species: Homo sapiens [TaxId:9606]
    Gene: CYP3A3, CYP3A4
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.02: d3nxub_
  • Heterogens: DMS, HEM, RIT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3nxuA (A:)
maygthshglfkklgipgptplpflgnilsyhkgfcmfdmechkkygkvwgfydgqqpvl
aitdpdmiktvlvkecysvftnrrpfgpvgfmksaisiaedeewkrlrsllsptftsgkl
kemvpiiaqygdvlvrnlrreaetgkpvtlkdvfgaysmdvitstsfgvnidslnnpqdp
fventkkllrfdfldpfflsitvfpflipilevlnicvfprevtnflrksvkrmkesrle
dtqkhrvdflqlmidsqnsketeshkalsdlelvaqsiififagyettssvlsfimyela
thpdvqqklqeeidavlpnkapptydtvlqmeyldmvvnetlrlfpiamrlervckkdve
ingmfipkgvvvmipsyalhrdpkywtepekflperfskknkdnidpyiytpfgsgprnc
igmrfalmnmklalirvlqnfsfkpcketqiplklslggllqpekpvvlkvesrdgtvsg
ahhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3nxuA (A:)
shglfkklgipgptplpflgnilsyhkgfcmfdmechkkygkvwgfydgqqpvlaitdpd
miktvlvkecysvftnrrpfgpvgfmksaisiaedeewkrlrsllsptftsgklkemvpi
iaqygdvlvrnlrreaetgkpvtlkdvfgaysmdvitstsfgvnidslnnpqdpfventk
kllrfdfldpfflsitvfpflipilevlnicvfprevtnflrksvkrmkesrledtrvdf
lqlmidsqnalsdlelvaqsiififagyettssvlsfimyelathpdvqqklqeeidavl
pnkapptydtvlqmeyldmvvnetlrlfpiamrlervckkdveingmfipkgvvvmipsy
alhrdpkywtepekflperfskknkdnidpyiytpfgsgprncigmrfalmnmklalirv
lqnfsfkpcketqiplklslggllqpekpvvlkvesr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3nxuB (B:)
maygthshglfkklgipgptplpflgnilsyhkgfcmfdmechkkygkvwgfydgqqpvl
aitdpdmiktvlvkecysvftnrrpfgpvgfmksaisiaedeewkrlrsllsptftsgkl
kemvpiiaqygdvlvrnlrreaetgkpvtlkdvfgaysmdvitstsfgvnidslnnpqdp
fventkkllrfdfldpfflsitvfpflipilevlnicvfprevtnflrksvkrmkesrle
dtqkhrvdflqlmidsqnsketeshkalsdlelvaqsiififagyettssvlsfimyela
thpdvqqklqeeidavlpnkapptydtvlqmeyldmvvnetlrlfpiamrlervckkdve
ingmfipkgvvvmipsyalhrdpkywtepekflperfskknkdnidpyiytpfgsgprnc
igmrfalmnmklalirvlqnfsfkpcketqiplklslggllqpekpvvlkvesrdgtvsg
ahhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3nxuB (B:)
shglfkklgipgptplpflgnilsyhkgfcmfdmechkkygkvwgfydgqqpvlaitdpd
miktvlvkecysvftnrrpfgpvgfmksaisiaedeewkrlrsllsptftsgklkemvpi
iaqygdvlvrnlrreaetgkpvtlkdvfgaysmdvitstsfgvnidslnnpqdpfventk
kllrfdfldpfflsitvfpflipilevlnicvfprevtnflrksvkrmkesrledtrvdf
lqlmidsqnalsdlelvaqsiififagyettssvlsfimyelathpdvqqklqeeidavl
pnkapptydtvlqmeyldmvvnetlrlfpiamrlervckkdveingmfipkgvvvmipsy
alhrdpkywtepekflperfskknkdnidpyiytpfgsgprncigmrfalmnmklalirv
lqnfsfkpcketqiplklslggllqpekpvvlkvesr