PDB entry 3ntz

View 3ntz on RCSB PDB site
Description: Design, Synthesis, Biological Evaluation and X-ray Crystal Structures of Novel Classical 6,5,6-tricyclicbenzo[4,5]thieno[2,3-d]pyrimidines as Dual Thymidylate Synthase and Dihydrofolate Reductase Inhibitors
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: dihydrofolate reductase, cyclized inhibitors, OXIDOREDUCTASE hDHFR-263-NADPH, Oxidoreductase-Oxidoreductase Inhibitor complex
Deposited on 2010-07-06, released 2011-05-25
The last revision prior to the SCOPe 2.04 freeze date was dated 2011-06-15, with a file datestamp of 2011-06-10.
Experiment type: XRAY
Resolution: 1.35 Å
R-factor: 0.187
AEROSPACI score: 0.7 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydrofolate reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: DHFR, DHFRP1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3ntza_
  • Heterogens: 3TZ, NDP, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3ntzA (A:)
vgslncivavsqnmgigkngdlpwpplrnefryfqrmtttssvegkqnlvimgkktwfsi
peknrplkgrinlvlsrelkeppqgahflsrslddalklteqpelankvdmvwivggssv
ykeamnhpghlklfvtrimqdfesdtffpeidlekykllpeypgvlsdvqeekgikykfe
vyeknd