PDB entry 3n7o

View 3n7o on RCSB PDB site
Description: X-ray structure of human chymase in complex with small molecule inhibitor.
Class: hydrolase
Keywords: serine protease, HYDROLASE
Deposited on 2010-05-27, released 2010-07-21
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: N/A
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Chymase
    Species: Homo sapiens [TaxId:9606]
    Gene: chymase (16-245), CMA1, CYH, CYM
    Database cross-references and differences (RAF-indexed):
    • Uniprot P23946 (0-225)
      • engineered mutation (190)
      • engineered mutation (215)
    Domains in SCOPe 2.08: d3n7oa_
  • Heterogens: N7O, UNL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3n7oA (A:)
iiggteckphsrpymayleivtsngpskfcggflirrnfvltaahcagrsitvtlgahni
teeedtwqklevikqfrhpkyntstlhhdimllklkekasltlavgtlpfpsqfnfvppg
rmcrvagwgrtgvlkpgsdtlqevklrlmdpqacshfrdfdhnlqlcvgnprktksafkg
dsggpllcagaaqgivsygrsdakppavftrishyqpwinqilqan

    Sequence, based on observed residues (ATOM records): (download) 
    >3n7oA (A:)
iiggteckphsrpymayleivtsngpskfcggflirrnfvltaahcagrsitvtlgahni
teeedtwqklevikqfrhpkyntstlhhdimllklkekasltlavgtlpfpsfvppgrmc
rvagwgrtgvlkpgsdtlqevklrlmdpqacshfrdfdhnlqlcvgnprktksafkgdsg
gpllcagaaqgivsygrsdakppavftrishyqpwinqilqan