PDB entry 3mhu

View 3mhu on RCSB PDB site
Description: Crystal structure of dihydroorotate dehydrogenase from Leishmania major in complex with 5-Nitroorotic acid
Class: oxidoreductase
Keywords: dihydroorotate dehydrogenase, pyrd, Oxidoreductase
Deposited on 2010-04-08, released 2011-02-23
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-02-23, with a file datestamp of 2011-02-18.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: 0.16
AEROSPACI score: 0.52 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydroorotate dehydrogenase
    Species: Leishmania major [TaxId:347515]
    Gene: LmjF16.0530
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q4QEW7 (34-345)
      • expression tag (32-33)
    Domains in SCOPe 2.07: d3mhua1, d3mhua2
  • Chain 'B':
    Compound: dihydroorotate dehydrogenase
    Species: Leishmania major [TaxId:347515]
    Gene: LmjF16.0530
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q4QEW7 (34-345)
      • expression tag (32-33)
    Domains in SCOPe 2.07: d3mhub1, d3mhub2
  • Heterogens: FMN, EJZ, GOL, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3mhuA (A:)
mgsshhhhhhssglvpagshmasmtggqqmgrgsmslqvnllnntfanpfmnaagvmctt
teelvamtesasgslvsksctpalregnptpryqalplgsinsmglpnngfdfylayaae
qhdygkkplflsmsglsmrenvemckrlaavatekgvilelnlscpnvpgkpqvaydfda
mrqcltavsevyphsfgvkmppyfdfahfdaaaeilnefpkvqfitcinsignglvidae
tesvvikpkqgfgglggryvlptalaninafyrrcpgklifgcggvytgedaflhvlaga
smvqvgtalqeegpsiferltsellgvmakkryqtldefrgkvrtl

    Sequence, based on observed residues (ATOM records): (download) 
    >3mhuA (A:)
gsmslqvnllnntfanpfmnaagvmcttteelvamtesasgslvsksctpalregnptpr
yqalplgsinsmglpnngfdfylayaaeqhdygkkplflsmsglsmrenvemckrlaava
tekgvilelnlscqvaydfdamrqcltavsevyphsfgvkmppyfdfahfdaaaeilnef
pkvqfitcinsignglvidaetesvvikpkqgfgglggryvlptalaninafyrrcpgkl
ifgcggvytgedaflhvlagasmvqvgtalqeegpsiferltsellgvmakkryqtldef
rgkvrtl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3mhuB (B:)
mgsshhhhhhssglvpagshmasmtggqqmgrgsmslqvnllnntfanpfmnaagvmctt
teelvamtesasgslvsksctpalregnptpryqalplgsinsmglpnngfdfylayaae
qhdygkkplflsmsglsmrenvemckrlaavatekgvilelnlscpnvpgkpqvaydfda
mrqcltavsevyphsfgvkmppyfdfahfdaaaeilnefpkvqfitcinsignglvidae
tesvvikpkqgfgglggryvlptalaninafyrrcpgklifgcggvytgedaflhvlaga
smvqvgtalqeegpsiferltsellgvmakkryqtldefrgkvrtl

    Sequence, based on observed residues (ATOM records): (download) 
    >3mhuB (B:)
gsmslqvnllnntfanpfmnaagvmcttteelvamtesasgslvsksctpalregnptpr
yqalplgsinsmglpnngfdfylayaaeqhdygkkplflsmsglsmrenvemckrlaava
tekgvilelnlscpqvaydfdamrqcltavsevyphsfgvkmppyfdfahfdaaaeilne
fpkvqfitcinsignglvidaetesvvikpkqgfgglggryvlptalaninafyrrcpgk
lifgcggvytgedaflhvlagasmvqvgtalqeegpsiferltsellgvmakkryqtlde
frgkvrtl