PDB entry 3ma2

View 3ma2 on RCSB PDB site
Description: Complex membrane type-1 matrix metalloproteinase (MT1-MMP) with tissue inhibitor of metalloproteinase-1 (TIMP-1)
Class: hydrolase/hydrolase inhibitor
Keywords: Protein - protein complex, Cleavage on pair of basic residues, Disulfide bond, Membrane, Metal-binding, Metalloprotease, Protease, Transmembrane, Zymogen, Erythrocyte maturation, Glycoprotein, Metalloenzyme inhibitor, Metalloprotease inhibitor, Secreted, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2010-03-23, released 2010-06-30
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-01-28, with a file datestamp of 2015-01-23.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: 0.199
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Matrix metalloproteinase-14
    Species: Homo sapiens [TaxId:9606]
    Gene: MMP14
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3ma2a_
  • Chain 'B':
    Compound: Metalloproteinase inhibitor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: TIMP1, CLGI, TIMP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01033 (0-End)
      • engineered (3)
      • engineered (5)
      • engineered (97)
    Domains in SCOPe 2.08: d3ma2b_
  • Chain 'C':
    Compound: Metalloproteinase inhibitor 1
    Species: Homo sapiens [TaxId:9606]
    Gene: TIMP1, CLGI, TIMP
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01033 (0-End)
      • engineered (3)
      • engineered (5)
      • engineered (97)
    Domains in SCOPe 2.08: d3ma2c_
  • Chain 'D':
    Compound: Matrix metalloproteinase-14
    Species: Homo sapiens [TaxId:9606]
    Gene: MMP14
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d3ma2d_
  • Heterogens: CA, ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3ma2A (A:)
    yaiqglkwqhneitfciqnytpkvgeyatyeairkafrvwesatplrfrevpyayiregh
    ekqadimiffaegfhgdstpfdgeggflahayfpgpniggdthfdsaepwtvrnedlngn
    diflvavhelghalglehssdpsaimapfyqwmdtenfvlpdddrrgiqqlyggesgfpt
    k
    

    Sequence, based on observed residues (ATOM records): (download)
    >3ma2A (A:)
    lkwqhneitfciqnytpkvgeyatyeairkafrvwesatplrfrevpyayireghekqad
    imiffaegfhgdstpfdgeggflahayfpgpniggdthfdsaepwtvrnedlngndiflv
    avhelghalglehssdpsaimapfyqwmdtenfvlpdddrrgiqqlyg
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >3ma2B (B:)
    ctcapvhpqtafcnsdlvirakfvgtpevnqttlyqryeikmtkmykgfqalgdaadirf
    vytpamesvcgyfhrshnrseefliagklqdgllhitlcsfvapwnslslaqrrgftkty
    tvgce
    

    Sequence, based on observed residues (ATOM records): (download)
    >3ma2B (B:)
    ctcapvhpqtafcnsdlvirakfvgtpevnqttlyqryeikmtkmykgfdirfvytpame
    svcgyfhrshnrseefliagklqdgllhitlcsfvapwnslslaqrrgftktytvgc
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >3ma2C (C:)
    ctcapvhpqtafcnsdlvirakfvgtpevnqttlyqryeikmtkmykgfqalgdaadirf
    vytpamesvcgyfhrshnrseefliagklqdgllhitlcsfvapwnslslaqrrgftkty
    tvgce
    

    Sequence, based on observed residues (ATOM records): (download)
    >3ma2C (C:)
    ctcapvhpqtafcnsdlvirakfvgtpevnqttlyqryeikmtkmykgfqaadirfvytp
    amesvcgyfhrsnrseefliagklqdgllhitlcsfvapwnslslaqrrgftktytvgc
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >3ma2D (D:)
    yaiqglkwqhneitfciqnytpkvgeyatyeairkafrvwesatplrfrevpyayiregh
    ekqadimiffaegfhgdstpfdgeggflahayfpgpniggdthfdsaepwtvrnedlngn
    diflvavhelghalglehssdpsaimapfyqwmdtenfvlpdddrrgiqqlyggesgfpt
    k
    

    Sequence, based on observed residues (ATOM records): (download)
    >3ma2D (D:)
    qglkwqhneitfciqnytpkvgeyatyeairkafrvwesatplrfrevpyayireghekq
    adimiffaegfhgdstpfdgeggflahayfpgpniggdthfdsaepwtvrnedlngndif
    lvavhelghalglehssdpsaimapfyqwmdtenfvlpdddrrgiqqlygg