PDB entry 3m2l

View 3m2l on RCSB PDB site
Description: Crystal structure of the M113F mutant of alpha-hemolysin
Class: toxin
Keywords: beta barrel, pore-forming toxin, Cytolysis, Hemolysis, Secreted, Toxin
Deposited on 2010-03-07, released 2010-05-12
The last revision prior to the SCOPe 2.02 freeze date was dated 2010-07-07, with a file datestamp of 2010-07-02.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.241
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: alpha-hemolysin
    Species: Staphylococcus aureus [TaxId:1280]
    Gene: hly, hla
    Database cross-references and differences (RAF-indexed):
    • Uniprot P09616 (1-293)
      • engineered (113)
    Domains in SCOPe 2.02: d3m2la_
  • Chain 'B':
    Compound: alpha-hemolysin
    Species: Staphylococcus aureus [TaxId:1280]
    Gene: hly, hla
    Database cross-references and differences (RAF-indexed):
    • Uniprot P09616 (1-293)
      • engineered (113)
    Domains in SCOPe 2.02: d3m2lb_
  • Chain 'C':
    Compound: alpha-hemolysin
    Species: Staphylococcus aureus [TaxId:1280]
    Gene: hly, hla
    Database cross-references and differences (RAF-indexed):
    • Uniprot P09616 (1-293)
      • engineered (113)
    Domains in SCOPe 2.02: d3m2lc_
  • Chain 'D':
    Compound: alpha-hemolysin
    Species: Staphylococcus aureus [TaxId:1280]
    Gene: hly, hla
    Database cross-references and differences (RAF-indexed):
    • Uniprot P09616 (1-293)
      • engineered (113)
    Domains in SCOPe 2.02: d3m2ld_
  • Chain 'E':
    Compound: alpha-hemolysin
    Species: Staphylococcus aureus [TaxId:1280]
    Gene: hly, hla
    Database cross-references and differences (RAF-indexed):
    • Uniprot P09616 (1-293)
      • engineered (113)
    Domains in SCOPe 2.02: d3m2le_
  • Chain 'F':
    Compound: alpha-hemolysin
    Species: Staphylococcus aureus [TaxId:1280]
    Gene: hly, hla
    Database cross-references and differences (RAF-indexed):
    • Uniprot P09616 (1-293)
      • engineered (113)
    Domains in SCOPe 2.02: d3m2lf_
  • Chain 'G':
    Compound: alpha-hemolysin
    Species: Staphylococcus aureus [TaxId:1280]
    Gene: hly, hla
    Database cross-references and differences (RAF-indexed):
    • Uniprot P09616 (1-293)
      • engineered (113)
    Domains in SCOPe 2.02: d3m2lg_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3m2lA (A:)
madsdiniktgttdigsnttvktgdlvtydkengmhkkvfysfiddknhnkkllvirtkg
tiagqyrvyseeganksglawpsafkvqlqlpdnevaqisdyyprnsidtkeyfstltyg
fngnvtgddtgkiggliganvsightlkyvqpdfktilesptdkkvgwkvifnnmvnqnw
gpydrdswnpvygnqlfmktrngsmkaadnfldpnkassllssgfspdfatvitmdrkas
kqqtnidviyervrddyqlhwtstnwkgtntkdkwtdrsserykidwekeemtn

    Sequence, based on observed residues (ATOM records): (download) 
    >3m2lA (A:)
adsdiniktgttdigsnttvktgdlvtydkengmhkkvfysfiddknhnkkllvirtkgt
iagqyrvyseeganksglawpsafkvqlqlpdnevaqisdyyprnsidtkeyfstltygf
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pydrdswnpvygnqlfmktrngsmkaadnfldpnkassllssgfspdfatvitmdrkask
qqtnidviyervrddyqlhwtstnwkgtntkdkwtdrsserykidwekeemtn

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3m2lB (B:)
madsdiniktgttdigsnttvktgdlvtydkengmhkkvfysfiddknhnkkllvirtkg
tiagqyrvyseeganksglawpsafkvqlqlpdnevaqisdyyprnsidtkeyfstltyg
fngnvtgddtgkiggliganvsightlkyvqpdfktilesptdkkvgwkvifnnmvnqnw
gpydrdswnpvygnqlfmktrngsmkaadnfldpnkassllssgfspdfatvitmdrkas
kqqtnidviyervrddyqlhwtstnwkgtntkdkwtdrsserykidwekeemtn

    Sequence, based on observed residues (ATOM records): (download) 
    >3m2lB (B:)
adsdiniktgttdigsnttvktgdlvtydkengmhkkvfysfiddknhnkkllvirtkgt
iagqyrvyseeganksglawpsafkvqlqlpdnevaqisdyyprnsidtkeyfstltygf
ngnvtgddtgkiggliganvsightlkyvqpdfktilesptdkkvgwkvifnnmvnqnwg
pydrdswnpvygnqlfmktrngsmkaadnfldpnkassllssgfspdfatvitmdrkask
qqtnidviyervrddyqlhwtstnwkgtntkdkwtdrsserykidwekeemtn

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3m2lC (C:)
madsdiniktgttdigsnttvktgdlvtydkengmhkkvfysfiddknhnkkllvirtkg
tiagqyrvyseeganksglawpsafkvqlqlpdnevaqisdyyprnsidtkeyfstltyg
fngnvtgddtgkiggliganvsightlkyvqpdfktilesptdkkvgwkvifnnmvnqnw
gpydrdswnpvygnqlfmktrngsmkaadnfldpnkassllssgfspdfatvitmdrkas
kqqtnidviyervrddyqlhwtstnwkgtntkdkwtdrsserykidwekeemtn

    Sequence, based on observed residues (ATOM records): (download) 
    >3m2lC (C:)
adsdiniktgttdigsnttvktgdlvtydkengmhkkvfysfiddknhnkkllvirtkgt
iagqyrvyseeganksglawpsafkvqlqlpdnevaqisdyyprnsidtkeyfstltygf
ngnvtgddtgkiggliganvsightlkyvqpdfktilesptdkkvgwkvifnnmvnqnwg
pydrdswnpvygnqlfmktrngsmkaadnfldpnkassllssgfspdfatvitmdrkask
qqtnidviyervrddyqlhwtstnwkgtntkdkwtdrsserykidwekeemtn

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3m2lD (D:)
madsdiniktgttdigsnttvktgdlvtydkengmhkkvfysfiddknhnkkllvirtkg
tiagqyrvyseeganksglawpsafkvqlqlpdnevaqisdyyprnsidtkeyfstltyg
fngnvtgddtgkiggliganvsightlkyvqpdfktilesptdkkvgwkvifnnmvnqnw
gpydrdswnpvygnqlfmktrngsmkaadnfldpnkassllssgfspdfatvitmdrkas
kqqtnidviyervrddyqlhwtstnwkgtntkdkwtdrsserykidwekeemtn

    Sequence, based on observed residues (ATOM records): (download) 
    >3m2lD (D:)
adsdiniktgttdigsnttvktgdlvtydkengmhkkvfysfiddknhnkkllvirtkgt
iagqyrvyseeganksglawpsafkvqlqlpdnevaqisdyyprnsidtkeyfstltygf
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pydrdswnpvygnqlfmktrngsmkaadnfldpnkassllssgfspdfatvitmdrkask
qqtnidviyervrddyqlhwtstnwkgtntkdkwtdrsserykidwekeemtn

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >3m2lE (E:)
madsdiniktgttdigsnttvktgdlvtydkengmhkkvfysfiddknhnkkllvirtkg
tiagqyrvyseeganksglawpsafkvqlqlpdnevaqisdyyprnsidtkeyfstltyg
fngnvtgddtgkiggliganvsightlkyvqpdfktilesptdkkvgwkvifnnmvnqnw
gpydrdswnpvygnqlfmktrngsmkaadnfldpnkassllssgfspdfatvitmdrkas
kqqtnidviyervrddyqlhwtstnwkgtntkdkwtdrsserykidwekeemtn

    Sequence, based on observed residues (ATOM records): (download) 
    >3m2lE (E:)
adsdiniktgttdigsnttvktgdlvtydkengmhkkvfysfiddknhnkkllvirtkgt
iagqyrvyseeganksglawpsafkvqlqlpdnevaqisdyyprnsidtkeyfstltygf
ngnvtgddtgkiggliganvsightlkyvqpdfktilesptdkkvgwkvifnnmvnqnwg
pydrdswnpvygnqlfmktrngsmkaadnfldpnkassllssgfspdfatvitmdrkask
qqtnidviyervrddyqlhwtstnwkgtntkdkwtdrsserykidwekeemtn

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >3m2lF (F:)
madsdiniktgttdigsnttvktgdlvtydkengmhkkvfysfiddknhnkkllvirtkg
tiagqyrvyseeganksglawpsafkvqlqlpdnevaqisdyyprnsidtkeyfstltyg
fngnvtgddtgkiggliganvsightlkyvqpdfktilesptdkkvgwkvifnnmvnqnw
gpydrdswnpvygnqlfmktrngsmkaadnfldpnkassllssgfspdfatvitmdrkas
kqqtnidviyervrddyqlhwtstnwkgtntkdkwtdrsserykidwekeemtn

    Sequence, based on observed residues (ATOM records): (download) 
    >3m2lF (F:)
adsdiniktgttdigsnttvktgdlvtydkengmhkkvfysfiddknhnkkllvirtkgt
iagqyrvyseeganksglawpsafkvqlqlpdnevaqisdyyprnsidtkeyfstltygf
ngnvtgddtgkiggliganvsightlkyvqpdfktilesptdkkvgwkvifnnmvnqnwg
pydrdswnpvygnqlfmktrngsmkaadnfldpnkassllssgfspdfatvitmdrkask
qqtnidviyervrddyqlhwtstnwkgtntkdkwtdrsserykidwekeemtn

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >3m2lG (G:)
madsdiniktgttdigsnttvktgdlvtydkengmhkkvfysfiddknhnkkllvirtkg
tiagqyrvyseeganksglawpsafkvqlqlpdnevaqisdyyprnsidtkeyfstltyg
fngnvtgddtgkiggliganvsightlkyvqpdfktilesptdkkvgwkvifnnmvnqnw
gpydrdswnpvygnqlfmktrngsmkaadnfldpnkassllssgfspdfatvitmdrkas
kqqtnidviyervrddyqlhwtstnwkgtntkdkwtdrsserykidwekeemtn

    Sequence, based on observed residues (ATOM records): (download) 
    >3m2lG (G:)
adsdiniktgttdigsnttvktgdlvtydkengmhkkvfysfiddknhnkkllvirtkgt
iagqyrvyseeganksglawpsafkvqlqlpdnevaqisdyyprnsidtkeyfstltygf
ngnvtgddtgkiggliganvsightlkyvqpdfktilesptdkkvgwkvifnnmvnqnwg
pydrdswnpvygnqlfmktrngsmkaadnfldpnkassllssgfspdfatvitmdrkask
qqtnidviyervrddyqlhwtstnwkgtntkdkwtdrsserykidwekeemtn