PDB entry 3lpb

View 3lpb on RCSB PDB site
Description: Crystal structure of Jak2 complexed with a potent 2,8-diaryl-quinoxaline inhibitor
Class: transferase
Keywords: Small molecule inhibitor, ATP site kinase inhibitor, Novartis product NVP-BLU040, ATP-binding, Chromosomal rearrangement, Disease mutation, Kinase, Membrane, Nucleotide-binding, Phosphoprotein, Polymorphism, Proto-oncogene, SH2 domain, Transferase, Tyrosine-protein kinase
Deposited on 2010-02-05, released 2010-04-28
The last revision prior to the SCOPe 2.07 freeze date was dated 2010-04-28, with a file datestamp of 2010-04-23.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.178
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3lpba_
  • Chain 'B':
    Compound: Tyrosine-protein kinase JAK2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60674 (2-294)
      • expression tag (1)
    Domains in SCOPe 2.07: d3lpbb1, d3lpbb2
  • Heterogens: NVB, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3lpbA (A:)
gsdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfer
eieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllqyt
sqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgesp
ifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfh
liellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmag

    Sequence, based on observed residues (ATOM records): (download) 
    >3lpbA (A:)
tqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfereiei
lkslqhdnivkykgvcynlklimeylpygslrdylqkhkeridhikllqytsqickgmey
lgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgespifwyapesl
teskfsvasdvwsfgvvlyelftyieksksppaefmrmigqmivfhliellknngrlprp
dgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnma

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3lpbB (B:)
gsdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfer
eieilkslqhdnivkykgvcysagrrnlklimeylpygslrdylqkhkeridhikllqyt
sqickgmeylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkepgesp
ifwyapeslteskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfh
liellknngrlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmag

    Sequence, based on observed residues (ATOM records): (download) 
    >3lpbB (B:)
sdptqfeerhlkflqqlgkgnfgsvemcrydplqdntgevvavkklqhsteehlrdfere
ieilkslqhdnivkykgvcynlklimeylpygslrdylqkhkeridhikllqytsqickg
meylgtkryihrdlatrnilvenenrvkigdfgltkvlpqdkeyykvkespifwyapesl
teskfsvasdvwsfgvvlyelftyieksksppaefmrmigndkqgqmivfhliellknng
rlprpdgcpdeiymimtecwnnnvnqrpsfrdlalrvdqirdnmag