PDB entry 3lcd

View 3lcd on RCSB PDB site
Description: Inhibitor Bound to A DFG-In structure of the Kinase Domain of CSF-1R
Class: transferase
Keywords: Kinase CFMS CSF-1R CSF tyrosine-kinase colony stimulating factor 1 receptor, ATP-binding, Disulfide bond, Glycoprotein, Immunoglobulin domain, Kinase, Membrane, Nucleotide-binding, Phosphoprotein, Proto-oncogene, Receptor, Transferase, Transmembrane, Tyrosine-protein kinase
Deposited on 2010-01-10, released 2010-03-02
The last revision prior to the SCOPe 2.04 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.218
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Macrophage colony-stimulating factor 1 receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: CSF-1R, CSF1R, FMS
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d3lcda_
  • Heterogens: SO4, BDY, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3lcdA (A:)
gvdykykqkpkyqvrwkiiesyegnsytfidptqlpynekwefprnnlqfgktlgagafg
kvveatafglgkedavlkvavkmlkstahadekealmselkimshlgqhenivnllgact
hggpvlviteyccygdllnflrrkaeadldkedgrplelrdllhfssqvaqgmaflaskn
cihrdvaarnvlltnghvakigdfglardimndsnyivkgnarlpvkwmapesifdcvyt
vqsdvwsygillweifslglnpypgilvnskfyklvkdgyqmaqpafapkniysimqacw
alepthrptfqqicsflqeqaqedrrerd

    Sequence, based on observed residues (ATOM records): (download) 
    >3lcdA (A:)
gnsytfidptqlpynekwefprnnlqfgktlgagafgkvveatafglgkedavlkvavkm
lkstahadekealmselkimshlgqhenivnllgacthggpvlviteyccygdllnflrr
kaeadldplelrdllhfssqvaqgmaflaskncihrdvaarnvlltnghvakigdfglar
dimsnyivkgnarlpvkwmapesifdcvytvqsdvwsygillweifslglnpypgilvns
kfyklvkdgyqmaqpafapkniysimqacwalepthrptfqqicsflqeq