PDB entry 3l5s

View 3l5s on RCSB PDB site
Description: Crystal structure of macrophage migration inhibitory factor (MIF) with imidazopyrimidinylphenyl inhibitor at 1.86A resolution
Class: isomerase
Keywords: PROTEIN-LIGAND COMPLEX, CYTOKINE, CYTOPLASM, IMMUNE RESPONSE, INFLAMMATORY RESPONSE, INNATE IMMUNITY, ISOMERASE, PHOSPHOPROTEIN, SECRETED, Acetylation
Deposited on 2009-12-22, released 2010-03-09
The last revision prior to the SCOPe 2.01 freeze date was dated 2010-03-09, with a file datestamp of 2010-03-05.
Experiment type: XRAY
Resolution: 1.86 Å
R-factor: 0.186
AEROSPACI score: 0.5 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: macrophage migration inhibitory factor
    Species: Homo sapiens [TaxId:9606]
    Gene: GLIF, MIF, MMIF
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3l5sa_
  • Chain 'B':
    Compound: macrophage migration inhibitory factor
    Species: Homo sapiens [TaxId:9606]
    Gene: GLIF, MIF, MMIF
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14174 (0-113)
      • expression tag (114-116)
    Domains in SCOPe 2.01: d3l5sb_
  • Chain 'C':
    Compound: macrophage migration inhibitory factor
    Species: Homo sapiens [TaxId:9606]
    Gene: GLIF, MIF, MMIF
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14174 (0-113)
      • expression tag (114-116)
    Domains in SCOPe 2.01: d3l5sc_
  • Heterogens: 88X, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3l5sA (A:)
pmfivntnvprasvpdgflseltqqlaqatgkppqyiavhvvpdqlmafggssepcalcs
lhsigkiggaqnrsyskllcgllaerlrispdrvyinyydmnaanvgwnnstfalehhhh
hh

    Sequence, based on observed residues (ATOM records): (download) 
    >3l5sA (A:)
pmfivntnvprasvpdgflseltqqlaqatgkppqyiavhvvpdqlmafggssepcalcs
lhsigkiggaqnrsyskllcgllaerlrispdrvyinyydmnaanvgwnnstfa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3l5sB (B:)
pmfivntnvprasvpdgflseltqqlaqatgkppqyiavhvvpdqlmafggssepcalcs
lhsigkiggaqnrsyskllcgllaerlrispdrvyinyydmnaanvgwnnstfalehhhh
hh

    Sequence, based on observed residues (ATOM records): (download) 
    >3l5sB (B:)
pmfivntnvprasvpdgflseltqqlaqatgkppqyiavhvvpdqlmafggssepcalcs
lhsigkiggaqnrsyskllcgllaerlrispdrvyinyydmnaanvgwnnstfaleh

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3l5sC (C:)
pmfivntnvprasvpdgflseltqqlaqatgkppqyiavhvvpdqlmafggssepcalcs
lhsigkiggaqnrsyskllcgllaerlrispdrvyinyydmnaanvgwnnstfalehhhh
hh

    Sequence, based on observed residues (ATOM records): (download) 
    >3l5sC (C:)
pmfivntnvprasvpdgflseltqqlaqatgkppqyiavhvvpdqlmafggssepcalcs
lhsigkiggaqnrsyskllcgllaerlrispdrvyinyydmnaanvgwnnstfaleh