PDB entry 3k2h

View 3k2h on RCSB PDB site
Description: Co-crystal structure of dihydrofolate reductase/thymidylate synthase from Babesia bovis with dUMP, Pemetrexed and NADP
Class: transferase
Keywords: NIAID, SSGCID, Seattle Structural Genomics Center for Infectious Disease, Alimta, folic acid analog, thyA, folate antimetabolites, tic-borne parasitic protozoan, babesiosis, malaria-like disease, Methyltransferase, Transferase
Deposited on 2009-09-30, released 2009-10-13
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-01, with a file datestamp of 2017-10-27.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: N/A
AEROSPACI score: 0.27 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Dihydrofolate reductase/thymidylate synthase
    Species: Babesia bovis [TaxId:5865]
    Gene: BBOV_II000780
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3k2ha1, d3k2ha2
  • Chain 'B':
    Compound: Dihydrofolate reductase/thymidylate synthase
    Species: Babesia bovis [TaxId:5865]
    Gene: BBOV_II000780
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3k2hb1, d3k2hb2
  • Heterogens: UMP, LYA, NAP, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3k2hA (A:)
msnsyegcgdltifvavalnkvighknqipwphithdfrflrngttyippevlsknpdiq
nvvifgrktyesipkaslplknrinvilsrtvkevpgclvyedlstairdlranvphnki
filggsflykevldnglcdkiyltrlnkeypgdtyfpdipdtfeitaisptfstdfvsyd
fviyerkdcktvfpdppfdqllmtgtdisvpkpkyvacpgvrirnheefqyldiladvls
hgvlkpnrtgtdayskfgyqmrfdlsrsfpllttkkvalrsiieellwfikgstngndll
aknvriwelngrrdfldkngftdreehdlgpiygfqwrhfgaeyldmhadytgkgidqla
eiinriktnpndrrlivcswnvsdlkkmalppchcffqfyvsdnklscmmhqrscdlglg
vpfniasysiltamvaqvcglglgefvhnladahiyvdhvdavttqiariphpfprlrln
pdirniedftiddivvedyvshppipmamsa

    Sequence, based on observed residues (ATOM records): (download) 
    >3k2hA (A:)
syegcgdltifvavalnkvighknqipwphithdfrflrngttyippevlsknpdiqnvv
ifgrktyesipkaslplknrinvilsrtvkevpgclvyedlstairdlranvphnkifil
ggsflykevldnglcdkiyltrlnkeypgdtyfpdipdtfeitaisptfstdfvsydfvi
yerkdckppfdqllmtgtdisvpkpkyvacpgvrirnheefqyldiladvlshgvlkpnr
tgtdayskfgyqmrfdlsrsfpllttkkvalrsiieellwfikgstngndllaknvriwe
lngrrdfldkngftdreehdlgpiygfqwrhfgaeyldmhadytgkgidqlaeiinrikt
npndrrlivcswnvsdlkkmalppchcffqfyvsdnklscmmhqrscdlglgvpfniasy
siltamvaqvcglglgefvhnladahiyvdhvdavttqiariphpfprlrlnpdirnied
ftiddivvedyvshppipmamsa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3k2hB (B:)
msnsyegcgdltifvavalnkvighknqipwphithdfrflrngttyippevlsknpdiq
nvvifgrktyesipkaslplknrinvilsrtvkevpgclvyedlstairdlranvphnki
filggsflykevldnglcdkiyltrlnkeypgdtyfpdipdtfeitaisptfstdfvsyd
fviyerkdcktvfpdppfdqllmtgtdisvpkpkyvacpgvrirnheefqyldiladvls
hgvlkpnrtgtdayskfgyqmrfdlsrsfpllttkkvalrsiieellwfikgstngndll
aknvriwelngrrdfldkngftdreehdlgpiygfqwrhfgaeyldmhadytgkgidqla
eiinriktnpndrrlivcswnvsdlkkmalppchcffqfyvsdnklscmmhqrscdlglg
vpfniasysiltamvaqvcglglgefvhnladahiyvdhvdavttqiariphpfprlrln
pdirniedftiddivvedyvshppipmamsa

    Sequence, based on observed residues (ATOM records): (download) 
    >3k2hB (B:)
syegcgdltifvavalnkvighknqipwphithdfrflrngttyippevlsknpdiqnvv
ifgrktyesipkaslplknrinvilsrtvkevpgclvyedlstairdlranvphnkifil
ggsflykevldnglcdkiyltrlnkeypgdtyfpdipdtfeitaisptfstdfvsydfvi
yerkdckppfdqllmtgtdisvpkpkyvacpgvrirnheefqyldiladvlshgvlkpnr
tgtdayskfgyqmrfdlsrsfpllttkkvalrsiieellwfikgstngndllaknvriwe
lngrrdfldkngftdreehdlgpiygfqwrhfgaeyldmhadytgkgidqlaeiinrikt
npndrrlivcswnvsdlkkmalppchcffqfyvsdnklscmmhqrscdlglgvpfniasy
siltamvaqvcglglgefvhnladahiyvdhvdavttqiariphpfprlrlnpdirnied
ftiddivvedyvshppipmamsa