PDB entry 3jya
View 3jya on RCSB PDB site
Description: Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors
Class: transferase
Keywords: PIM-1, Alternative initiation, ATP-binding, Cell membrane, Cytoplasm, Kinase, Manganese, Membrane, Metal-binding, Nucleotide-binding, Nucleus, Phosphoprotein, Polymorphism, Proto-oncogene, Serine/threonine-protein kinase, Transferase
Deposited on
2009-09-21, released
2009-11-10
The last revision prior to the SCOPe 2.06 freeze date was dated
2009-11-10, with a file datestamp of
2009-11-06.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.234
AEROSPACI score: 0.39
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Proto-oncogene serine/threonine-protein kinase Pim-1
Species: Homo sapiens [TaxId:9606]
Gene: PIM1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d3jyaa_ - Heterogens: LWG
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3jyaA (A:)
mkekeplesqyqvgpllgsggfgsvysgirvsdnlpvaikhvekdrisdwgelpngtrvp
mevvllkkvssgfsgvirlldwferpdsfvlilerpepvqdlfdfitergalqeelarsf
fwqvleavrhchncgvlhrdikdenilidlnrgelklidfgsgallkdtvytdfdgtrvy
sppewiryhryhgrsaavwslgillydmvcgdipfehdeeiirgqvffrqrvssecqhli
rwclalrpsdrptfeeiqnhpwmqdvllpqetaeihlhslspgpskvdhhhhhh
Sequence, based on observed residues (ATOM records): (download)
>3jyaA (A:)
plesqyqvgpllgsggfgsvysgirvsdnlpvaikhvekdrisdwgelpngtrvpmevvl
lkkvssgfsgvirlldwferpdsfvlilerpepvqdlfdfitergalqeelarsffwqvl
eavrhchncgvlhrdikdenilidlnrgelklidfgsgallkdtvytdfdgtrvysppew
iryhryhgrsaavwslgillydmvcgdipfehdeeiirgqvffrqrvssecqhlirwcla
lrpsdrptfeeiqnhpwmqdvllpqetaeihlhs