SCOPe 2.04: Structural Classification of Proteins

PDB entry 3inl

View 3inl on RCSB PDB site
Description: Human Mitochondrial Aldehyde Dehydrogenase Asian Variant, ALDH2*2, complexed with agonist Alda-1
Class: oxidoreductase
Keywords: oxidoreductase, ALDH, E487K, Rossmann fold, Alda-1, activator, Mitochondrion, NAD, Transit peptide
Deposited on 2009-08-12, released 2010-01-12
The last revision prior to the SCOPe 2.04 freeze date was dated 2010-08-11, with a file datestamp of 2010-08-06.
Experiment type: XRAY
Resolution: 1.86 Å
R-factor: 0.136
AEROSPACI score: 0.54 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: aldehyde dehydrogenase, mitochondrial
Species: Homo sapiens [TaxId:9606]
Gene: ALDH2, ALDM
Database cross-references and differences (RAF-indexed):
- Uniprot P05091 (Start-499)
  - engineered (301)
  - engineered (486)
Domains in SCOPe 2.04: d3inla_
Chain 'B':
Compound: aldehyde dehydrogenase, mitochondrial
Species: Homo sapiens [TaxId:9606]
Gene: ALDH2, ALDM
Database cross-references and differences (RAF-indexed):
- Uniprot P05091 (Start-499)
  - engineered (301)
  - engineered (486)
Domains in SCOPe 2.04: d3inlb_
Chain 'C':
Compound: aldehyde dehydrogenase, mitochondrial
Species: Homo sapiens [TaxId:9606]
Gene: ALDH2, ALDM
Database cross-references and differences (RAF-indexed):
- Uniprot P05091 (Start-499)
  - engineered (301)
  - engineered (486)
Domains in SCOPe 2.04: d3inlc_
Chain 'D':
Compound: aldehyde dehydrogenase, mitochondrial
Species: Homo sapiens [TaxId:9606]
Gene: ALDH2, ALDM
Database cross-references and differences (RAF-indexed):
- Uniprot P05091 (Start-499)
  - engineered (301)
  - engineered (486)
Domains in SCOPe 2.04: d3inld_
Chain 'E':
Compound: aldehyde dehydrogenase, mitochondrial
Species: Homo sapiens [TaxId:9606]
Gene: ALDH2, ALDM
Database cross-references and differences (RAF-indexed):
- Uniprot P05091 (Start-499)
  - engineered (301)
  - engineered (486)
Domains in SCOPe 2.04: d3inle_
Chain 'F':
Compound: aldehyde dehydrogenase, mitochondrial
Species: Homo sapiens [TaxId:9606]
Gene: ALDH2, ALDM
Database cross-references and differences (RAF-indexed):
- Uniprot P05091 (Start-499)
  - engineered (301)
  - engineered (486)
Domains in SCOPe 2.04: d3inlf_
Chain 'G':
Compound: aldehyde dehydrogenase, mitochondrial
Species: Homo sapiens [TaxId:9606]
Gene: ALDH2, ALDM
Database cross-references and differences (RAF-indexed):
- Uniprot P05091 (Start-499)
  - engineered (301)
  - engineered (486)
Domains in SCOPe 2.04: d3inlg_
Chain 'H':
Compound: aldehyde dehydrogenase, mitochondrial
Species: Homo sapiens [TaxId:9606]
Gene: ALDH2, ALDM
Database cross-references and differences (RAF-indexed):
- Uniprot P05091 (Start-499)
  - engineered (301)
  - engineered (486)
Domains in SCOPe 2.04: d3inlh_
Heterogens: NA, EDO, BXB, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>3inlA (A:)
saaatqavpapnqqpevfcnqifinnewhdavsrktfptvnpstgevicqvaegdkedvd
kavkaaraafqlgspwrrmdashrgrllnrladlierdrtylaaletldngkpyvisylv
dldmvlkclryyagwadkyhgktipidgdffsytrhepvgvcgqiipwnfpllmqawklg
palatgnvvvmkvaeqtpltalyvanlikeagfppgvvnivpgfgptagaaiashedvdk
vaftgsteigrviqvaagssnlkrvtlelggkspniimsdadmdwaveqahfalffnqgq
cscagsrtfvqediydefversvaraksrvvgnpfdskteqgpqvdetqfkkilgyintg
kqegakllcgggiaadrgyfiqptvfgdvqdgmtiakeeifgpvmqilkfktieevvgra
nnstyglaaavftkdldkanylsqalqagtvwvncydvfgaqspfggykmsgsgrelgey
glqaytkvktvtvkvpqkns