PDB entry 3ii6

View 3ii6 on RCSB PDB site
Description: Structure of human Xrcc4 in complex with the tandem BRCT domains of DNA LigaseIV.
Class: ligase/DNA binding protein
Keywords: XRCC4, DNA LIGASE IV, NHEJ, DNA REPAIR, BRCT, Alternative splicing, Coiled coil, DNA damage, DNA recombination, Isopeptide bond, Nucleus, Phosphoprotein, Polymorphism, Ubl conjugation, ATP-binding, Cell cycle, Cell division, Disease mutation, DNA replication, Ligase, Magnesium, Metal-binding, Nucleotide-binding, SCID, LIGASE/DNA BINDING PROTEIN COMPLEX
Deposited on 2009-07-31, released 2009-08-11
The last revision prior to the SCOPe 2.05 freeze date was dated 2009-08-11, with a file datestamp of 2009-08-07.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.24
AEROSPACI score: 0.26 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: DNA repair protein xrcc4
    Species: Homo sapiens [TaxId:9606]
    Gene: XRCC4
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13426 (0-End)
      • engineered (59)
      • engineered (133)
    Domains in SCOPe 2.05: d3ii6a1, d3ii6a2
  • Chain 'B':
    Compound: DNA repair protein xrcc4
    Species: Homo sapiens [TaxId:9606]
    Gene: XRCC4
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13426 (0-End)
      • engineered (59)
      • engineered (133)
    Domains in SCOPe 2.05: d3ii6b1, d3ii6b2
  • Chain 'C':
    Compound: DNA repair protein xrcc4
    Species: Homo sapiens [TaxId:9606]
    Gene: XRCC4
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13426 (0-End)
      • engineered (59)
      • engineered (133)
    Domains in SCOPe 2.05: d3ii6c1, d3ii6c2
  • Chain 'D':
    Compound: DNA repair protein xrcc4
    Species: Homo sapiens [TaxId:9606]
    Gene: XRCC4
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q13426 (0-End)
      • engineered (59)
      • engineered (133)
    Domains in SCOPe 2.05: d3ii6d1, d3ii6d2
  • Chain 'X':
    Compound: DNA ligase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: LIG4
    Database cross-references and differences (RAF-indexed):
  • Chain 'Y':
    Compound: DNA ligase 4
    Species: Homo sapiens [TaxId:9606]
    Gene: LIG4
    Database cross-references and differences (RAF-indexed):
  • Heterogens: CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3ii6A (A:)
merkisrihlvsepsithflqvswektlesgfvitltdghsawtgtvseseisqeaddme
mekgkyvgelrkallsgagpadvytfnfskescyfffeknlkdvsfrlgsfnlekvenpa
evirelicycldttaenqaknehlqkenerllrdwndvqgrfekcvsakealetdlykrf
ilvlnekktkirslhnkllnaaq

    Sequence, based on observed residues (ATOM records): (download) 
    >3ii6A (A:)
merkisrihlvsepsithflqvswektlesgfvitltdghsawtgtvseseisqeaddme
mekgkyvgelrkallsgagpadvytfnfskescyfffeknlkdvsfrlgsfnlekvenpa
evirelicycldttaenqaknehlqkenerllrdwndvqgrfekcvsakealetdlykrf
ilvlnekktkirslhnkllna

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3ii6B (B:)
merkisrihlvsepsithflqvswektlesgfvitltdghsawtgtvseseisqeaddme
mekgkyvgelrkallsgagpadvytfnfskescyfffeknlkdvsfrlgsfnlekvenpa
evirelicycldttaenqaknehlqkenerllrdwndvqgrfekcvsakealetdlykrf
ilvlnekktkirslhnkllnaaq

    Sequence, based on observed residues (ATOM records): (download) 
    >3ii6B (B:)
merkisrihlvsepsithflqvswektlesgfvitltdghsawtgtvseseisqeaddme
mekgkyvgelrkallsdvytfnfskescyfffeknlkdvsfrlgsfnlekvenpaevire
licycldttaenqaknehlqkenerllrdwndvqgrfekcvsakealetdlykrfilvln
ekktkirslhnkllna

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3ii6C (C:)
merkisrihlvsepsithflqvswektlesgfvitltdghsawtgtvseseisqeaddme
mekgkyvgelrkallsgagpadvytfnfskescyfffeknlkdvsfrlgsfnlekvenpa
evirelicycldttaenqaknehlqkenerllrdwndvqgrfekcvsakealetdlykrf
ilvlnekktkirslhnkllnaaq

    Sequence, based on observed residues (ATOM records): (download) 
    >3ii6C (C:)
merkisrihlvsepsithflqvswektlesgfvitltdghsawtgtvseseisqeaddme
mekgkyvgelrkallsgagpadvytfnfskescyfffeknlkdvsfrlgsfnlekvenpa
evirelicycldttaenqaknehlqkenerllrdwndvqgrfekcvsakealetdlykrf
ilvlnekktkirslhnkllna

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3ii6D (D:)
merkisrihlvsepsithflqvswektlesgfvitltdghsawtgtvseseisqeaddme
mekgkyvgelrkallsgagpadvytfnfskescyfffeknlkdvsfrlgsfnlekvenpa
evirelicycldttaenqaknehlqkenerllrdwndvqgrfekcvsakealetdlykrf
ilvlnekktkirslhnkllnaaq

    Sequence, based on observed residues (ATOM records): (download) 
    >3ii6D (D:)
merkisrihlvsepsithflqvswektlesgfvitltdghsawtgtvseseisqeaddme
mekgkyvgelrkallsvytfnfskescyfffeknlkdvsfrlgsfnlekvenpaevirel
icycldttaenqaknehlqkenerllrdwndvqgrfekcvsakealetdlykrfilvlne
kktkirslhnkllna

  • Chain 'X':
    No sequence available.

  • Chain 'Y':
    No sequence available.