PDB entry 3igk

View 3igk on RCSB PDB site
Description: Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs (p53-DNA complex 2)
Class: transcription/DNA
Keywords: P53, MUTANT PROTEIN, LOOP-SHEET-HELIX MOTIF, DNA TARGET, ACTIVATOR, ANTI-ONCOGENE APOPTOSIS, CELL CYCLE, COVALENT PROTEIN-RNA LINKAGE, DISEASE MUTATION, DNA-BINDING, ENDOPLASMIC RETICULUM, GLYCOPROTEIN, HOST-VIRUS INTERACTION, LI-FRAUMENI SYNDROME, METAL-BINDING, METHYLATION, NUCLEUS, PHOSPHOPROTEIN, TRANSCRIPTION, TRANSCRIPTION REGULATION, TRANSCRIPTION-DNA COMPLEX, Apoptosis, Isopeptide bond, Tumor suppressor
Deposited on 2009-07-28, released 2010-03-31
The last revision prior to the SCOPe 2.08 freeze date was dated 2011-06-08, with a file datestamp of 2011-06-03.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.153
AEROSPACI score: 0.58 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Cellular tumor antigen p53
  Species: Homo sapiens [TaxId:9606]
  Gene: TP53
  Database cross-references and differences (RAF-indexed):
  • Uniprot P04637 (0-199)
    • engineered mutation (74)
    • engineered mutation (155)
  Domains in SCOPe 2.08: d3igka_
• Chain 'B':
  Compound: DNA (5'-d(*cp*gp*gp*gp*cp*ap*tp*gp*cp*cp*cp*g)-3')
  Species: synthetic, synthetic
  
• Heterogens: ZN, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence, based on SEQRES records: (download)
  

  >3igkA (A:)
  sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
  gtrvramaiykqsqrmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfr
  hsvvvpyeppevgsdcttihynymcnsscmggmnrspiltiitledssgnllgrnsfevr
  vcacpgrdrrteeenlrkkg
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >3igkA (A:)
  sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
  gtrvramaiykqsqrmtevvrrcphhercsglappqhlirvegnlrveylddrntfrhsv
  vvpyeppevgsdcttihynymcnsscmggmnrspiltiitledssgnllgrnsfevrvca
  cpgrdrrteeenlrkkg
  

  
  
• Chain 'B':
  No sequence available.