PDB entry 3iai

View 3iai on RCSB PDB site
Description: Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX
Class: lyase
Keywords: CARBONIC ANHYDRASES, TRANSMEMBRANE PROTEINS, Cell membrane, Cell projection, Disulfide bond, Glycoprotein, Lyase, Membrane, Metal-binding, Nucleus, Phosphoprotein, Transmembrane
Deposited on 2009-07-14, released 2009-09-08
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.157
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Carbonic anhydrase 9
    Species: Homo sapiens [TaxId:9606]
    Gene: CA9, G250, MN
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16790 (Start-256)
      • expression tag (0)
      • expression tag (0)
      • engineered (39)
    Domains in SCOPe 2.06: d3iaia1, d3iaia2
  • Chain 'B':
    Compound: Carbonic anhydrase 9
    Species: Homo sapiens [TaxId:9606]
    Gene: CA9, G250, MN
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16790 (Start-256)
      • engineered (39)
    Domains in SCOPe 2.06: d3iaib_
  • Chain 'C':
    Compound: Carbonic anhydrase 9
    Species: Homo sapiens [TaxId:9606]
    Gene: CA9, G250, MN
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16790 (Start-256)
      • engineered (39)
    Domains in SCOPe 2.06: d3iaic_
  • Chain 'D':
    Compound: Carbonic anhydrase 9
    Species: Homo sapiens [TaxId:9606]
    Gene: CA9, G250, MN
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q16790 (Start-256)
      • engineered (39)
    Domains in SCOPe 2.06: d3iaid_
  • Heterogens: ZN, AZM, GOL, TRS, PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3iaiA (A:)
gpdqshwryggdppwprvspacagrfqspvdirpqlaafspalrplellgfqlpplpelr
lrnnghsvqltlppglemalgpgreyralqlhlhwgaagrpgsehtveghrfpaeihvvh
lstafarvdealgrpgglavlaafleegpeensayeqllsrleeiaeegsetqvpgldis
allpsdfsryfqyegslttppcaqgviwtvfnqtvmlsakqlhtlsdtlwgpgdsrlqln
fratqplngrvieasfp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3iaiB (B:)
gpdqshwryggdppwprvspacagrfqspvdirpqlaafspalrplellgfqlpplpelr
lrnnghsvqltlppglemalgpgreyralqlhlhwgaagrpgsehtveghrfpaeihvvh
lstafarvdealgrpgglavlaafleegpeensayeqllsrleeiaeegsetqvpgldis
allpsdfsryfqyegslttppcaqgviwtvfnqtvmlsakqlhtlsdtlwgpgdsrlqln
fratqplngrvieasfp

    Sequence, based on observed residues (ATOM records): (download) 
    >3iaiB (B:)
hwryggdppwprvspacagrfqspvdirpqlaafspalrplellgfqlpplpelrlrnng
hsvqltlppglemalgpgreyralqlhlhwgaagrpgsehtveghrfpaeihvvhlstaf
arvdealgrpgglavlaafleegpeensayeqllsrleeiaeegsetqvpgldisallps
dfsryfqyegslttppcaqgviwtvfnqtvmlsakqlhtlsdtlwgpgdsrlqlnfratq
plngrvieasfp

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3iaiC (C:)
gpdqshwryggdppwprvspacagrfqspvdirpqlaafspalrplellgfqlpplpelr
lrnnghsvqltlppglemalgpgreyralqlhlhwgaagrpgsehtveghrfpaeihvvh
lstafarvdealgrpgglavlaafleegpeensayeqllsrleeiaeegsetqvpgldis
allpsdfsryfqyegslttppcaqgviwtvfnqtvmlsakqlhtlsdtlwgpgdsrlqln
fratqplngrvieasfp

    Sequence, based on observed residues (ATOM records): (download) 
    >3iaiC (C:)
hwryggdppwprvspacagrfqspvdirpqlaafspalrplellgfqlpplpelrlrnng
hsvqltlppglemalgpgreyralqlhlhwgaagrpgsehtveghrfpaeihvvhlstaf
arvdealgrpgglavlaafleegpeensayeqllsrleeiaeegsetqvpgldisallps
dfsryfqyegslttppcaqgviwtvfnqtvmlsakqlhtlsdtlwgpgdsrlqlnfratq
plngrvieasfp

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3iaiD (D:)
gpdqshwryggdppwprvspacagrfqspvdirpqlaafspalrplellgfqlpplpelr
lrnnghsvqltlppglemalgpgreyralqlhlhwgaagrpgsehtveghrfpaeihvvh
lstafarvdealgrpgglavlaafleegpeensayeqllsrleeiaeegsetqvpgldis
allpsdfsryfqyegslttppcaqgviwtvfnqtvmlsakqlhtlsdtlwgpgdsrlqln
fratqplngrvieasfp

    Sequence, based on observed residues (ATOM records): (download) 
    >3iaiD (D:)
shwryggdppwprvspacagrfqspvdirpqlaafspalrplellgfqlpplpelrlrnn
ghsvqltlppglemalgpgreyralqlhlhwgaagrpgsehtveghrfpaeihvvhlsta
farvdealgrpgglavlaafleegpeensayeqllsrleeiaeegsetqvpgldisallp
sdfsryfqyegslttppcaqgviwtvfnqtvmlsakqlhtlsdtlwgpgdsrlqlnfrat
qplngrvieasfp