PDB entry 3i8v

View 3i8v on RCSB PDB site
Description: Crystal structure of human PDE4a with 4-(3-butoxy-4-methoxyphenyl)methyl-2-imidazolidone
Class: hydrolase
Keywords: cyclic-AMP specific, cAMP, Hydrolase, Membrane, Phosphoprotein
Deposited on 2009-07-10, released 2009-07-21
The last revision prior to the SCOPe 2.02 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 2.25 Å
R-factor: 0.189
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: cAMP-specific 3',5'-cyclic phosphodiesterase 4A
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE4A, DPDE2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27815 (21-353)
      • expression tag (19-20)
  • Chain 'B':
    Compound: cAMP-specific 3',5'-cyclic phosphodiesterase 4A
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE4A, DPDE2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P27815 (21-353)
      • expression tag (20)
    Domains in SCOPe 2.02: d3i8vb_
  • Heterogens: ZN, MG, 0MO, GOL, CO, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3i8vB (B:)
mgsshhhhhhssglvprgshmniprfgvktdqeellaqelenlnkwglnifcvsdyaggr
sltcimymifqerdllkkfripvdtmvtymltledhyhadvayhnslhaadvlqsthvll
atpaldavftdleilaalfaaaihdvdhpgvsnqflintnselalmyndesvlenhhlav
gfkllqedncdifqnlskrqrqslrkmvidmvlatdmskhmtlladlktmvetkkvtssg
vllldnysdriqvlrnmvhcadlsnptkplelyrqwtdrimaeffqqgdrerergmeisp
mcdkhtasveksqvgfidyivhplwetwadlvhpdaqeildtlednrdwyysai

    Sequence, based on observed residues (ATOM records): (download) 
    >3i8vB (B:)
mniprfgvktdqeellaqelenlnkwglnifcvsdyaggrsltcimymifqerdllkkfr
ipvdtmvtymltledhyhadvayhnslhaadvlqsthvllatpaldavftdleilaalfa
aaihdvdhpgvsnqflintnselalmyndesvlenhhlavgfkllqedncdifqnlskrq
rqslrkmvidmvlatdmskhmtlladlktmvetkkvtssgvllldnysdriqvlrnmvhc
adlsnptkplelyrqwtdrimaeffqqgdrerergmeispmcdkhtasveksqvgfidyi
vhplwetwadlvhpdaqeildtlednrdwyysai