PDB entry 3hmi
View 3hmi on RCSB PDB site
Description: The crystal structure of human ABL2 in complex with 5-AMINO-3-{[4-(AMINOSULFONYL)PHENYL]AMINO}-N-(2,6-DIFLUOROPHENYL)-1H-1,2,4-TRIAZOLE-1-CARBOTHIOAMIDE
Class: transferase
Keywords: Tyrosine kinase, ABL, ABL2, Abelson murine leukemia viral oncogene, ATP-binding, Cell adhesion, Cytoskeleton, Kinase, Lipoprotein, Magnesium, Manganese, Metal-binding, Myristate, Nucleotide-binding, Phosphoprotein, SH2 domain, SH3 domain, Transferase, Tyrosine-protein kinase, Structural Genomics, Structural Genomics Consortium, SGC
Deposited on
2009-05-29, released
2009-07-07
The last revision prior to the SCOPe 2.06 freeze date was dated
2011-07-13, with a file datestamp of
2011-05-08.
Experiment type: XRAY
Resolution: 1.65 Å
R-factor: 0.19
AEROSPACI score: 0.57
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Tyrosine-protein kinase ABL2
Species: Homo sapiens [TaxId:9606]
Gene: ABL2
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d3hmia_ - Heterogens: DKI, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>3hmiA (A:)
mghhhhhhssgvdlgtenlyfqsmdkwemertditmkhklgggqygevyvgvwkkysltv
avktlkedtmeveeflkeaavmkeikhpnlvqllgvctleppfyivteympygnlldylr
ecnreevtavvllymatqissameylekknfihrdlaarnclvgenhvvkvadfglsrlm
tgdtytahagakfpikwtapeslayntfsiksdvwafgvllweiatygmspypgidlsqv
ydllekgyrmeqpegcppkvyelmracwkwspadrpsfaethqafetmfhds
Sequence, based on observed residues (ATOM records): (download)
>3hmiA (A:)
dkwemertditmkhklgggqygevyvgvwkkysltvavktlkedtmeveeflkeaavmke
ikhpnlvqllgvctleppfyivteympygnlldylrecnreevtavvllymatqissame
ylekknfihrdlaarnclvgenhvvkvadfglsrlmtgdtytahagakfpikwtapesla
yntfsiksdvwafgvllweiatygmspypgidlsqvydllekgyrmeqpegcppkvyelm
racwkwspadrpsfaethqafetmfhds