SCOPe 2.03: Structural Classification of Proteins

PDB entry 3gxm

View 3gxm on RCSB PDB site
Description: Crystal structure of acid-beta-glucosidase at pH 4.5, phosphate crystallization condition
Class: hydrolase
Keywords: hydrolase, Alternative initiation, Disease mutation, Disulfide bond, Gaucher disease, Glycoprotein, Glycosidase, Ichthyosis, Lipid metabolism, Lysosome, Membrane, Sphingolipid metabolism
Deposited on 2009-04-02, released 2009-05-05
The last revision prior to the SCOPe 2.03 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.223
AEROSPACI score: 0.35 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: glucosylceramidase
Species: Homo sapiens [TaxId:9606]
Gene: GBA, GC, GLUC
Database cross-references and differences (RAF-indexed):
- Uniprot P04062 (0-496)
  - variant (494)
Domains in SCOPe 2.03: d3gxma1, d3gxma2
Chain 'B':
Compound: glucosylceramidase
Species: Homo sapiens [TaxId:9606]
Gene: GBA, GC, GLUC
Database cross-references and differences (RAF-indexed):
- Uniprot P04062 (0-496)
  - variant (494)
Domains in SCOPe 2.03: d3gxmb1, d3gxmb2
Chain 'C':
Compound: glucosylceramidase
Species: Homo sapiens [TaxId:9606]
Gene: GBA, GC, GLUC
Database cross-references and differences (RAF-indexed):
- Uniprot P04062 (0-496)
  - variant (494)
Domains in SCOPe 2.03: d3gxmc1, d3gxmc2
Chain 'D':
Compound: glucosylceramidase
Species: Homo sapiens [TaxId:9606]
Gene: GBA, GC, GLUC
Database cross-references and differences (RAF-indexed):
- Uniprot P04062 (0-496)
  - variant (494)
Domains in SCOPe 2.03: d3gxmd1, d3gxmd2
Heterogens: NAG, SO4, HOH

PDB Chain Sequences:

Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)

>3gxmA (A:)
arpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqanh
tgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyniir
vpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspwt
sptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsagl
lsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltdpe
aakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswdrg
mqyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyhl
ghfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavgfl
etispgysihtylwhrq

Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)

>3gxmB (B:)
arpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqanh
tgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyniir
vpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspwt
sptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsagl
lsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltdpe
aakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswdrg
mqyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyhl
ghfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavgfl
etispgysihtylwhrq

Chain 'C':
Sequence; same for both SEQRES and ATOM records: (download)

>3gxmC (C:)
arpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqanh
tgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyniir
vpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspwt
sptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsagl
lsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltdpe
aakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswdrg
mqyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyhl
ghfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavgfl
etispgysihtylwhrq

Chain 'D':
Sequence; same for both SEQRES and ATOM records: (download)

>3gxmD (D:)
arpcipksfgyssvvcvcnatycdsfdpptfpalgtfsryestrsgrrmelsmgpiqanh
tgtgllltlqpeqkfqkvkgfggamtdaaalnilalsppaqnlllksyfseegigyniir
vpmascdfsirtytyadtpddfqlhnfslpeedtklkiplihralqlaqrpvsllaspwt
sptwlktngavngkgslkgqpgdiyhqtwaryfvkfldayaehklqfwavtaenepsagl
lsgypfqclgftpehqrdfiardlgptlansthhnvrllmlddqrlllphwakvvltdpe
aakyvhgiavhwyldflapakatlgethrlfpntmlfaseacvgskfweqsvrlgswdrg
mqyshsiitnllyhvvgwtdwnlalnpeggpnwvrnfvdspiivditkdtfykqpmfyhl
ghfskfipegsqrvglvasqkndldavalmhpdgsavvvvlnrsskdvpltikdpavgfl
etispgysihtylwhrq