PDB entry 3gsn

View 3gsn on RCSB PDB site
Description: Crystal structure of the public RA14 TCR in complex with the HCMV dominant NLV/HLA-A2 epitope
Class: immune system
Keywords: hla, human cytomegalovirus, pp65, t cell receptor (tcr), immune response, public response, immunodominance, restrained response, host-virus interaction, membrane, MHC I, polymorphism, immunoglobulin domain, immune system
Deposited on 2009-03-27, released 2009-08-04
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-08-04, with a file datestamp of 2009-07-31.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: 0.237
AEROSPACI score: 0.2 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: RA14 TCR alpha chain (TRAV24, TRAJ49)
    Species: Homo sapiens [TaxId:9606]
    Gene: TCR
    Database cross-references and differences (RAF-indexed):
    • PDB 3GSN (0-198)
    Domains in SCOPe 2.06: d3gsna1, d3gsna2
  • Chain 'B':
    Compound: RA14 TCR beta chain (TRBV6-5, TRBD1, TRBJ1-2)
    Species: Homo sapiens [TaxId:9606]
    Gene: TCR
    Database cross-references and differences (RAF-indexed):
    • PDB 3GSN (0-242)
    Domains in SCOPe 2.06: d3gsnb1, d3gsnb2
  • Chain 'H':
    Compound: HLA class I histocompatibility antigen, A-2 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA, HLA-A, HLAA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01892 (0-273)
      • engineered (244)
    Domains in SCOPe 2.06: d3gsnh1, d3gsnh2
  • Chain 'L':
    Compound: Beta-2-microglobulin
    Species: Homo sapiens [TaxId:9606]
    Gene: B2M, Beta-2 microglubulin, CDABP0092, HDCMA22P
    Database cross-references and differences (RAF-indexed):
    • Uniprot P61769 (1-99)
      • initiating methionine (0)
    Domains in SCOPe 2.06: d3gsnl1, d3gsnl2
  • Chain 'P':
    Compound: HCMV pp65 fragment 495-503 (NLVPMVATV)
    Database cross-references and differences (RAF-indexed):
    • PDB 3GSN (0-8)
  • Heterogens: SO4, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3gsnA (A:)
lnveqspqslhvqegdstnftcsfpssnfyalhwyrwetakspealfvmtlngdekkkgr
isatlntkegysylyikgsqpedsatylcarntgnqfyfgtgtsltvipniqnpdpavyq
lrdskssdksvclftdfdsqtnvsqskdsdayitdktvldmrsmdfksnsavawsnksdf
acanafnnsiipedtffps

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3gsnB (B:)
mgvtqtpkfqvlktgqsmtlqcaqdmnheymswyrqdpgmglrlihysvgagitdqgevp
ngynvsrsttedfplrllsaapsqtsvyfcasspvtggiygytfgsgtrltvvedlnkvf
ppevavfepseaeishtqkatlvclatgffpdhvelswwvngkevhsgvstdpqplkeqp
alndsryclssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawg
rad

  • Chain 'H':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3gsnH (H:)
gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
rtdapkthmthhavsdheatlrcwalsfypaeitltwqrdgedqtqdtelvetrpagdgt
fqkwvavvvpsgqeqrytchvqheglpkpltlrw

  • Chain 'L':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3gsnL (L:)
miqrtpkiqvysrhpaengksnflncyvsgfhpsdievdllkngeriekvehsdlsfskd
wsfyllyyteftptekdeyacrvnhvtlsqpkivkwdrdm

  • Chain 'P':
    No sequence available.