PDB entry 3gax

View 3gax on RCSB PDB site
Description: Crystal structure of monomeric human cystatin C stabilized against aggregation
Class: hydrolase inhibitor
Keywords: cysteine protease inhibitor, 3D domain swapping, protein aggregation, amyloid, protein engineering, twinning, Hereditary Cystatin C Amyloid Angiopathy, Amyloidosis, Disease mutation, Polymorphism, Protease inhibitor, Secreted, Thiol protease inhibitor, HYDROLASE INHIBITOR
Deposited on 2009-02-18, released 2010-02-23
The last revision prior to the SCOPe 2.02 freeze date was dated 2010-04-28, with a file datestamp of 2010-04-23.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.139
AEROSPACI score: 0.57 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cystatin-C
    Species: Homo sapiens [TaxId:9606]
    Gene: CST3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01034 (Start-119)
      • engineered (46)
      • engineered (68)
    Domains in SCOPe 2.02: d3gaxa_
  • Chain 'B':
    Compound: Cystatin-C
    Species: Homo sapiens [TaxId:9606]
    Gene: CST3
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01034 (Start-119)
      • engineered (46)
      • engineered (68)
    Domains in SCOPe 2.02: d3gaxb_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3gaxA (A:)
sspgkpprlvggpmdasveeegvrraldfavgeynkasndmyhsracqvvrarkqivagv
nyfldvelcrttctktqpnldncpfhdqphlkrkafcsfqiyavpwqgtmtlskstcqda

    Sequence, based on observed residues (ATOM records): (download) 
    >3gaxA (A:)
gpmdasveeegvrraldfavgeynkasndmyhsracqvvrarkqivagvnyfldvelcrt
tctktqldncpfhdqphlkrkafcsfqiyavpwqgtmtlskstcqda

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3gaxB (B:)
sspgkpprlvggpmdasveeegvrraldfavgeynkasndmyhsracqvvrarkqivagv
nyfldvelcrttctktqpnldncpfhdqphlkrkafcsfqiyavpwqgtmtlskstcqda

    Sequence, based on observed residues (ATOM records): (download) 
    >3gaxB (B:)
gpmdasveeegvrraldfavgeynkasndmyhsracqvvrarkqivagvnyfldvelcrt
tctktqpnncpfhdqphlkrkafcsfqiyavpwqgtmtlskstcqda