PDB entry 3g5e

View 3g5e on RCSB PDB site
Description: Human aldose reductase complexed with IDD 740 inhibitor
Class: oxidoreductase
Keywords: ALDOSE REDUCTASE, INHIBITION, DIABETES, Acetylation, Cataract, Cytoplasm, NADP, Oxidoreductase, Phosphoprotein, Polymorphism
Deposited on 2009-02-05, released 2009-03-24
The last revision prior to the SCOPe 2.04 freeze date was dated 2009-03-24, with a file datestamp of 2009-03-20.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.146
AEROSPACI score: 0.56 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: aldose reductase
    Species: Homo sapiens [TaxId:9606]
    Gene: AKR1B1, ALDR1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P15121 (3-318)
      • see remark 999 (7)
    Domains in SCOPe 2.04: d3g5ea_
  • Heterogens: NDP, Q74, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3g5eA (A:)
gshmasrillnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgv
aiqeklreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwptgfk
pgkeffpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglk
ykpavnqiechpyltqekliqycqskgivvtaysplgspdrpwakpedpslledprikai
aakhnkttaqvlirfpmqrnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwr
vcallsctshkdypfheef

    Sequence, based on observed residues (ATOM records): (download) 
    >3g5eA (A:)
masrillnngakmpilglgtwksppgqvteavkvaidvgyrhidcahvyqnenevgvaiq
eklreqvvkreelfivsklwctyhekglvkgacqktlsdlkldyldlylihwptgfkpgk
effpldesgnvvpsdtnildtwaameelvdeglvkaigisnfnhlqvemilnkpglkykp
avnqiechpyltqekliqycqskgivvtaysplgspdrpwakpedpslledprikaiaak
hnkttaqvlirfpmqrnlvvipksvtperiaenfkvfdfelssqdmttllsynrnwrvca
llsctshkdypfheef