PDB entry 3g1r

View 3g1r on RCSB PDB site
Description: Crystal structure of human liver 5beta-reductase (AKR1D1) in complex with NADP and Finasteride. Resolution 1.70 A
Class: oxidoreductase
Keywords: FINASTERIDE complex, Bile acid catabolism, Cytoplasm, Disease mutation, Intrahepatic cholestasis, Lipid metabolism, NADP, Oxidoreductase, Steroid metabolism
Deposited on 2009-01-30, released 2009-06-09
The last revision prior to the SCOPe 2.03 freeze date was dated 2010-01-05, with a file datestamp of 2009-12-31.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.177
AEROSPACI score: 0.56 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3-oxo-5-beta-steroid 4-dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Gene: AKR1D1, SRD5B1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d3g1ra_
  • Chain 'B':
    Compound: 3-oxo-5-beta-steroid 4-dehydrogenase
    Species: Homo sapiens [TaxId:9606]
    Gene: AKR1D1, SRD5B1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d3g1rb_
  • Heterogens: NAP, FIT, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3g1rA (A:)
mgsshhhhhhssglvprgshmdlsaashriplsdgnsipiiglgtysepkstpkgacats
vkvaidtgyrhidgayiyqnehevgeairekiaegkvrredifycgklwatnhvpemvrp
tlertlrvlqldyvdlyiievpmafkpgdeiyprdengkwlyhksnlcatweameackda
glvkslgvsnfnrrqlelilnkpglkhkpvsnqvechpyftqpkllkfcqqhdivitays
plgtsrnpiwvnvssppllkdallnslgkrynktaaqivlrfniqrgvvvipksfnleri
kenfqifdfslteeemkdiealnknvrfvellmwrdhpeypfhdey

    Sequence, based on observed residues (ATOM records): (download) 
    >3g1rA (A:)
dlsaashriplsdgnsipiiglgtysepkstpkgacatsvkvaidtgyrhidgayiyqne
hevgeairekiaegkvrredifycgklwatnhvpemvrptlertlrvlqldyvdlyiiev
pmafkpgdeiyprdengkwlyhksnlcatweameackdaglvkslgvsnfnrrqleliln
kpglkhkpvsnqvechpyftqpkllkfcqqhdivitaysplgtsrnpiwvnvssppllkd
allnslgkrynktaaqivlrfniqrgvvvipksfnlerikenfqifdfslteeemkdiea
lnknvrfvellmwrdhpeypfhdey

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3g1rB (B:)
mgsshhhhhhssglvprgshmdlsaashriplsdgnsipiiglgtysepkstpkgacats
vkvaidtgyrhidgayiyqnehevgeairekiaegkvrredifycgklwatnhvpemvrp
tlertlrvlqldyvdlyiievpmafkpgdeiyprdengkwlyhksnlcatweameackda
glvkslgvsnfnrrqlelilnkpglkhkpvsnqvechpyftqpkllkfcqqhdivitays
plgtsrnpiwvnvssppllkdallnslgkrynktaaqivlrfniqrgvvvipksfnleri
kenfqifdfslteeemkdiealnknvrfvellmwrdhpeypfhdey

    Sequence, based on observed residues (ATOM records): (download) 
    >3g1rB (B:)
dlsaashriplsdgnsipiiglgtysepkstpkgacatsvkvaidtgyrhidgayiyqne
hevgeairekiaegkvrredifycgklwatnhvpemvrptlertlrvlqldyvdlyiiev
pmafkpgdeiyprdengkwlyhksnlcatweameackdaglvkslgvsnfnrrqleliln
kpglkhkpvsnqvechpyftqpkllkfcqqhdivitaysplgtsrnpiwvnvssppllkd
allnslgkrynktaaqivlrfniqrgvvvipksfnlerikenfqifdfslteeemkdiea
lnknvrfvellmwrdhpeypfhdey