PDB entry 3eq6

View 3eq6 on RCSB PDB site
Description: Crystal structure of human acyl-CoA synthetase medium-chain family member 2A (L64P mutation) in a ternary complex with products
Class: ligase
Keywords: Middle-chain acyl-CoA synthetase, xenobiotic/medium-chain fatty acid-CoA ligase, ATP-binding, fatty acid metabolism, lipid metabolism, magnesium, metal-binding, mitochondrion, nucleotide-binding polymorphism, transit peptide, Ligase, Structural Genomics, SGC, Structural Genomics Consortium
Deposited on 2008-09-30, released 2008-10-28
The last revision prior to the SCOPe 2.04 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.189
AEROSPACI score: 0.37 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Acyl-coenzyme A synthetase ACSM2A
    Species: Homo sapiens [TaxId:9606]
    Gene: ACSM2A
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q08AH3
      • engineered mutation (56)
    Domains in SCOPe 2.04: d3eq6a_
  • Chain 'B':
    Compound: Acyl-coenzyme A synthetase ACSM2A
    Species: Homo sapiens [TaxId:9606]
    Gene: ACSM2A
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q08AH3
      • engineered mutation (56)
    Domains in SCOPe 2.04: d3eq6b_
  • Heterogens: AMP, BCO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3eq6A (A:)
mghhhhhhssgvdlgtenlyfqsmslqwghqevpakfnfasdvldhwadmekagkrppsp
alwwvngkgkelmwnfrelsensqqaanvlsgacglqrgdrvavvlprvpewwlvilgci
raglifmpgtiqmkstdilyrlqmskakaivagdeviqevdtvasecpslrikllvseks
cdgwlnfkkllneastthhcvetgsqeasaiyftsgtsglpkmaehsysslglkakmdag
wtglqasdimwtisdtgwilnilcslmepwalgactfvhllpkfdplvilktlssypiks
mmgapivyrmllqqdlssykfphlqncvtvgesllpetlenwraqtgldiresygqtetg
ltcmvsktmkikpgymgtaascydvqiiddkgnvlppgtegdigirvkpirpigifsgyv
dnpdktaanirgdfwllgdrgikdedgyfqfmgraddiinssgyrigpsevenalmehpa
vvetavisspdpvrgevvkafvvlasqflshdpeqltkelqqhvksvtapykyprkiefv
lnlpktvtgkiqraklrdkewkmsgkaraq

    Sequence, based on observed residues (ATOM records): (download) 
    >3eq6A (A:)
hqevpakfnfasdvldhwadmekagkrppspalwwvngkgkelmwnfrelsensqqaanv
lsgacglqrgdrvavvlprvpewwlvilgciraglifmpgtiqmkstdilyrlqmskaka
ivagdeviqevdtvasecpslrikllvsekscdgwlnfkkllneastthhcvetgsqeas
aiyftsgtsglpkmaehsysslglkakmdagwtglqasdimwtisdtgwilnilcslmep
walgactfvhllpkfdplvilktlssypiksmmgapivyrmllqqdlssykfphlqncvt
vgesllpetlenwraqtgldiresygqtetgltcmvsktmkikpgymgtaascydvqiid
dkgnvlppgtegdigirvkpirpigifsgyvdnpdktaanirgdfwllgdrgikdedgyf
qfmgraddiinssgyrigpsevenalmehpavvetavisspdpvrgevvkafvvlasqfl
shdpeqltkelqqhvksvtapykyprkiefvlnlpktvtgkiqraklrdkewk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3eq6B (B:)
mghhhhhhssgvdlgtenlyfqsmslqwghqevpakfnfasdvldhwadmekagkrppsp
alwwvngkgkelmwnfrelsensqqaanvlsgacglqrgdrvavvlprvpewwlvilgci
raglifmpgtiqmkstdilyrlqmskakaivagdeviqevdtvasecpslrikllvseks
cdgwlnfkkllneastthhcvetgsqeasaiyftsgtsglpkmaehsysslglkakmdag
wtglqasdimwtisdtgwilnilcslmepwalgactfvhllpkfdplvilktlssypiks
mmgapivyrmllqqdlssykfphlqncvtvgesllpetlenwraqtgldiresygqtetg
ltcmvsktmkikpgymgtaascydvqiiddkgnvlppgtegdigirvkpirpigifsgyv
dnpdktaanirgdfwllgdrgikdedgyfqfmgraddiinssgyrigpsevenalmehpa
vvetavisspdpvrgevvkafvvlasqflshdpeqltkelqqhvksvtapykyprkiefv
lnlpktvtgkiqraklrdkewkmsgkaraq

    Sequence, based on observed residues (ATOM records): (download) 
    >3eq6B (B:)
hqevpakfnfasdvldhwadmekagkrppspalwwvngkgkelmwnfrelsensqqaanv
lsgacglqrgdrvavvlprvpewwlvilgciraglifmpgtiqmkstdilyrlqmskaka
ivagdeviqevdtvasecpslrikllvsekscdgwlnfkkllneastthhcvetgsqeas
aiyftsgtsglpkmaehsysslglkakmdagwtglqasdimwtisdtgwilnilcslmep
walgactfvhllpkfdplvilktlssypiksmmgapivyrmllqqdlssykfphlqncvt
vgesllpetlenwraqtgldiresygqtetgltcmvsktmkikpgymgtaascydvqiid
dkgnvlppgtegdigirvkpirpigifsgyvdnpdktaanirgdfwllgdrgikdedgyf
qfmgraddiinssgyrigpsevenalmehpavvetavisspdpvrgevvkafvvlasqfl
shdpeqltkelqqhvksvtapykyprkiefvlnlpktvtgkiqraklrdkewk