PDB entry 3ene

View 3ene on RCSB PDB site
Description: Complex of PI3K gamma with an inhibitor
Class: transferase
Keywords: lipid kinase, phosphoinositide, inhibitor, 3-kinase, signaling, pyrazolopyrimidine, PIK-208, S2, Kinase, Transferase
Deposited on 2008-09-25, released 2008-10-14
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: 0.229
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
    Species: Homo sapiens [TaxId:9606]
    Gene: PIK3CG
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3enea1, d3enea2, d3enea3, d3enea4
  • Heterogens: NPZ, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3eneA (A:)
seesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvt
skplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakkkslmdipe
sqseqdfvlrvcgrdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkeew
plvddctgvtgyheqltihgkdhesvftvslwdcdrkfrvkirgidipvlprntdltvfv
eaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgallnlqiycgkapalss
kasaespsseskgkvrllyyvnlllidhrfllrrgeyvlhmwqisgkgedqgsfnadklt
satnpdkensmsisilldnychpialpkhqptpdpegdrvraempnqlrkqleaiiatdp
lnpltaedkellwhfryeslkhpkaypklfssvkwgqqeivaktyqllarrevwdqsald
vgltmqlldcnfsdenvraiavqklesledddvlhyllqlvqavkfepyhdsalarfllk
rglrnkrighflfwflrseiaqsrhyqqrfavileaylrgcgtamlhdftqqvqviemlq
kvtldikslsaekydvssqvisqlkqklenlqnsqlpesfrvpydpglkagalaiekckv
maskkkplwlefkcadptalsnetigiifkhgddlrqdmlilqilrimesiwetesldlc
llpygcistgdkigmieivkdattiakiqqstvgntgafkdevlnhwlkekspteekfqa
averfvyscagycvatfvlgigdrhndnimitetgnlfhidfghilgnyksflginkerv
pfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnlliilfsmmlmtgmpqlt
skedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflhlvlgikqgekhsa

    Sequence, based on observed residues (ATOM records): (download) 
    >3eneA (A:)
seesqafqrqltaligydvtdvsnvhddeleftrrglvtprmaevasrdpklyamhpwvt
skplpeylwkkianncifivihrsttsqtikvspddtpgailqsfftkmakqdfvlrvcg
rdeylvgetpiknfqwvrhclkngeeihvvldtppdpaldevrkeewcdrkfrvkirgid
ipvlprntdltvfveaniqhgqqvlcqrrtspkpfteevlwnvwlefsikikdlpkgall
nlqiycrllyyvnlllidhrfllrrgeyvlhmwqisgfnadkltsatnpdkensmsisil
ldnhpiaraempnqlrkqleaiiatdplnpltaedkellwhfryeslkhpkaypklfssv
kwgqqeivaktyqllarrevwdqsaldvgltmqlldcnfsdenvraiavqklesledddv
lhyllqlvqavkfepyhdsalarfllkrglrnkrighflfwflrseiaqsrhyqqrfavi
leaylrgcgtamlhdftqqvqviemlqkvtldikslsaekydvssqvisqlkqklenlqn
sqlpesfrvpydpglkagalaiekckvmaskkkplwlefkcadptalsnetigiifkhgd
dlrqdmlilqilrimesiwetesldlcllpygcistgdkigmieivkdattiakiqqstv
gntgafkdevlnhwlkekspteekfqaaverfvyscagycvatfvlgigdrhndnimite
tgnlfhidfghervpfvltpdflfvmgtsgkktsphfqkfqdicvkaylalrhhtnllii
lfsmmlmtgmpqltskedieyirdaltvgkneedakkyfldqievcrdkgwtvqfnwflh
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