PDB entry 3ecn
View 3ecn on RCSB PDB site
Description: Crystal structure of PDE8A catalytic domain in complex with IBMX
Class: hydrolase
Keywords: IBMX, PDE8A catalytic domain, refolding, Alternative splicing, cAMP, Hydrolase, Magnesium, Manganese, Metal-binding
Deposited on
2008-09-01, released
2008-11-25
The last revision prior to the SCOPe 2.07 freeze date was dated
2009-03-17, with a file datestamp of
2009-03-13.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.221
AEROSPACI score: 0.4
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
Species: Homo sapiens [TaxId:9606]
Gene: PDE8A
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d3ecna_ - Chain 'B':
Compound: High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
Species: Homo sapiens [TaxId:9606]
Gene: PDE8A
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d3ecnb_ - Heterogens: IBM, ZN, MG, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>3ecnA (A:)
ddvppriarameneeywdfdifeleaathnrpliylglkmfarfgiceflhcsestlrsw
lqiieanyhssnpyhnsthsadvlhatayflskeriketldpidevaaliaatihdvdhp
grtnsflcnagselailyndtavleshhaalafqlttgddkcnifknmerndyrtlrqgi
idmvlatemtkhfehvnkfvnsinkplatleengetdknqevintmlrtpenrtlikrml
ikcadvsnpcrplqyciewaariseeyfsqtdeekqqglpvvmpvfdrntcsipksqisf
idyfitdmfdawdafvdlpdlmqhldnnfkywkgldem
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>3ecnB (B:)
ddvppriarameneeywdfdifeleaathnrpliylglkmfarfgiceflhcsestlrsw
lqiieanyhssnpyhnsthsadvlhatayflskeriketldpidevaaliaatihdvdhp
grtnsflcnagselailyndtavleshhaalafqlttgddkcnifknmerndyrtlrqgi
idmvlatemtkhfehvnkfvnsinkplatleengetdknqevintmlrtpenrtlikrml
ikcadvsnpcrplqyciewaariseeyfsqtdeekqqglpvvmpvfdrntcsipksqisf
idyfitdmfdawdafvdlpdlmqhldnnfkywkgldem