PDB entry 3dyq

View 3dyq on RCSB PDB site
Description: human phosphodiestrase 9 (inhibited by omitting divalent cation) in complex with cGMP
Class: hydrolase
Keywords: PHOSPHODIESTERASE, ENZYME MECHANISM, cGMP, Hydrolase, Manganese, Metal-binding, Phosphoprotein
Deposited on 2008-07-28, released 2008-09-16
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.199
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE9A
    Database cross-references and differences (RAF-indexed):
    • Uniprot O76083 (4-End)
      • expression tag (0-3)
    Domains in SCOPe 2.07: d3dyqa2, d3dyqa3
  • Chain 'B':
    Compound: High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
    Species: Homo sapiens [TaxId:9606]
    Gene: PDE9A
    Database cross-references and differences (RAF-indexed):
    • Uniprot O76083 (4-End)
      • expression tag (0-3)
    Domains in SCOPe 2.07: d3dyqb2, d3dyqb3
  • Heterogens: NA, PCG, IBM, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3dyqA (A:)
gshmtypkyllspetiealrkptfdvwlwepnemlsclehmyhdlglvrdfsinpvtlrr
wlfcvhdnyrnnpfhnfrhcfcvaqmmysmvwlcslqekfsqtdililmtaaichdldhp
gynntyqinartelavryndisplenhhcavafqilaepecnifsnippdgfkqirqgmi
tlilatdmarhaeimdsfkekmenfdysneehmtllkmilikccdisnevrpmevaepwv
dclleeyfmqsdrekseglpvapfmdrdkvtkataqigfikfvlipmfetvtklfpmvee
imlqplwesrdryeelkriddamkelqkk

    Sequence, based on observed residues (ATOM records): (download) 
    >3dyqA (A:)
gshmtypkyllspetiealrkptfdvwlwepnemlsclehmyhdlglvrdfsinpvtlrr
wlfcvhdnyrnnpfhnfrhcfcvaqmmysmvwlcslqekfsqtdililmtaaichdldhp
gynntyqinartelavryndisplenhhcavafqilaepecnifsnippdgfkqirqgmi
tlilatdmarhaeimdsfkekmenfdysneehmtllkmilikccdisnevrpmevaepwv
dclleeyfmqsdrekseglpvapfmdrdkvtkataqigfikfvlipmfetvtklfpmvee
imlqplwesrdryeelkriddamkelqk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3dyqB (B:)
gshmtypkyllspetiealrkptfdvwlwepnemlsclehmyhdlglvrdfsinpvtlrr
wlfcvhdnyrnnpfhnfrhcfcvaqmmysmvwlcslqekfsqtdililmtaaichdldhp
gynntyqinartelavryndisplenhhcavafqilaepecnifsnippdgfkqirqgmi
tlilatdmarhaeimdsfkekmenfdysneehmtllkmilikccdisnevrpmevaepwv
dclleeyfmqsdrekseglpvapfmdrdkvtkataqigfikfvlipmfetvtklfpmvee
imlqplwesrdryeelkriddamkelqkk

    Sequence, based on observed residues (ATOM records): (download) 
    >3dyqB (B:)
gshmtypkyllspetiealrkptfdvwlwepnemlsclehmyhdlglvrdfsinpvtlrr
wlfcvhdnyrnnpfhnfrhcfcvaqmmysmvwlcslqekfsqtdililmtaaichdldhp
gynntyqinartelavryndisplenhhcavafqilaepecnifsnippdgfkqirqgmi
tlilatdmarhaeimdsfkekmenfdysneehmtllkmilikccdisnevrpmevaepwv
dclleeyfmqsdrekseglpvapfmdrdkvtkataqigfikfvlipmfetvtklfpmvee
imlqplwesrdryeelkriddamkelqk