PDB entry 3dkg

View 3dkg on RCSB PDB site
Description: Structure of Mutant(Y1248L) MET receptor tyrosine kinase in complex with inhibitor SGX-523
Class: oncoprotein
Keywords: DRUG DISCOVERY, c-MET KINASE, FRAGMENT BASED, Membrane, Receptor, Transmembrane, ONCOPROTEIN
Deposited on 2008-06-24, released 2009-07-07
The last revision prior to the SCOPe 2.07 freeze date was dated 2015-04-22, with a file datestamp of 2015-04-17.
Experiment type: XRAY
Resolution: 1.91 Å
R-factor: N/A
AEROSPACI score: 0.34 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Hepatocyte growth factor receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: MET, hCG_38705, tcag7.66
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08581
      • engineered mutation (148)
    Domains in SCOPe 2.07: d3dkga_
  • Heterogens: CL, SX8, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3dkgA (A:)
gslntvhidlsalnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlldndgkki
hcavkslnritdigevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdl
rnfirnethnptvkdligfglqvakgmkflaskkfvhrdlaarncmldekftvkvadfgl
ardmldkefdsvhnktgaklpvkwmaleslqtqkfttksdvwsfgvllwelmtrgappyp
dvntfditvyllqgrrllqpeycpdplyevmlkcwhpkaemrpsfselvsrisaifstfi
gehyvhvnatyvnvkeg

    Sequence, based on observed residues (ATOM records): (download) 
    >3dkgA (A:)
tvhidlsalnpelvqavqhvvigpsslivhfnevicvyhgtlldkkihcavkslnritdi
gevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrnfirnethnptv
kdligfglqvakgmkflaskkfvhrdlaarncmldekftvkvadfglarlpvkwmalesl
qtqkfttksdvwsfgvllwelmtrgappypdvntfditvyllqgrrllqpeycpdplyev
mlkcwhpkaemrpsfselvsrisaifstfigehyvhvnaty