PDB entry 3dg8

View 3dg8 on RCSB PDB site
Description: Quadruple mutant (N51I+C59R+S108N+I164L) Plasmodium falciparum dihydrofolate reductase-thymidylate synthase (PfDHFR-TS) complexed with RJF670, NADPH, and dUMP
Class: oxidoreductase, transferase
Keywords: Alpha-Beta, Methyltransferase, Oxidoreductase, Transferase
Deposited on 2008-06-13, released 2009-01-27
The last revision prior to the SCOPe 2.01 freeze date was dated 2009-01-27, with a file datestamp of 2009-03-01.
Experiment type: XRAY
Resolution: 2.58 Å
R-factor: 0.199
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Bifunctional dihydrofolate reductase-thymidylate synthase
    Species: Plasmodium falciparum [TaxId:5833]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8I1R6 (0-End)
      • engineered (50)
      • engineered (58)
      • engineered (107)
      • engineered (163)
  • Chain 'B':
    Compound: Bifunctional dihydrofolate reductase-thymidylate synthase
    Species: Plasmodium falciparum [TaxId:5833]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q8I1R6 (0-End)
      • engineered (50)
      • engineered (58)
      • engineered (107)
      • engineered (163)
  • Chain 'C':
    Compound: Bifunctional dihydrofolate reductase-thymidylate synthase
    Species: Plasmodium falciparum [TaxId:5833]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3dg8c_
  • Chain 'D':
    Compound: Bifunctional dihydrofolate reductase-thymidylate synthase
    Species: Plasmodium falciparum [TaxId:5833]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.01: d3dg8d_
  • Heterogens: RJ6, NDP, UMP, HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    No sequence available.

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3dg8C (C:)
ddddeeeddfvyfnfnkekeeknknsihpndfqiynslkykyhpeyqylniiydimmngn
kqsdrtgvgvlskfgyimkfdlsqyfpllttkklflrgiieellwfirgetngntllnkn
vriweangtrefldnrklfhrevndlgpiygfqwrhfgaeytnmydnyenkgvdqlknii
nlikndptsrrillcawnvkdldqmalppchilcqfyvfdgklscimyqrscdlglgvpf
niasysifthmiaqvcnlqpaqfihvlgnahvynnhidslkiqlnripypfptlklnpdi
kniedftisdftiqnyvhhekismdmaa

    Sequence, based on observed residues (ATOM records): (download) 
    >3dg8C (C:)
ddeeeddfvyfnfnkekeeknknsihpndfqiynslkykyhpeyqylniiydimmngnkq
sdrtgvgvlskfgyimkfdlsqyfpllttkklflrgiieellwfirgetngntllnknvr
iweangtrefldnrklfhrevndlgpiygfqwrhfgaeytnmydnyenkgvdqlkniinl
ikndptsrrillcawnvkdldqmalppchilcqfyvfdgklscimyqrscdlglgvpfni
asysifthmiaqvcnlqpaqfihvlgnahvynnhidslkiqlnripypfptlklnpdikn
iedftisdftiqnyvhhekismdmaa

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3dg8D (D:)
ddddeeeddfvyfnfnkekeeknknsihpndfqiynslkykyhpeyqylniiydimmngn
kqsdrtgvgvlskfgyimkfdlsqyfpllttkklflrgiieellwfirgetngntllnkn
vriweangtrefldnrklfhrevndlgpiygfqwrhfgaeytnmydnyenkgvdqlknii
nlikndptsrrillcawnvkdldqmalppchilcqfyvfdgklscimyqrscdlglgvpf
niasysifthmiaqvcnlqpaqfihvlgnahvynnhidslkiqlnripypfptlklnpdi
kniedftisdftiqnyvhhekismdmaa

    Sequence, based on observed residues (ATOM records): (download) 
    >3dg8D (D:)
ddeeeddfvyfnfnkekeeknknsihpndfqiynslkykyhpeyqylniiydimmngnkq
sdrtgvgvlskfgyimkfdlsqyfpllttkklflrgiieellwfirgetngntllnknvr
iweangtrefldnrklfhrevndlgpiygfqwrhfgaeytnmydnyenkgvdqlkniinl
ikndptsrrillcawnvkdldqmalppchilcqfyvfdgklscimyqrscdlglgvpfni
asysifthmiaqvcnlqpaqfihvlgnahvynnhidslkiqlnripypfptlklnpdikn
iedftisdftiqnyvhhekismdmaa