PDB entry 3ddq

View 3ddq on RCSB PDB site
Description: Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor roscovitine
Class: transferase/cell cycle
Keywords: Ser/Thr protein kinase; transferase; phosphorylation; cell cycle, ATP-binding, Cell cycle, Cell division, Kinase, Mitosis, Nucleotide-binding, Phosphoprotein, Polymorphism, Serine/threonine-protein kinase, Cyclin, Cytoplasm, Nucleus, TRANSFERASE/CELL CYCLE COMPLEX
Deposited on 2008-06-06, released 2008-07-22
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-02-24, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.195
AEROSPACI score: 0.5 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cell division protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CDK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P24941 (1-298)
      • expression tag (0)
    Domains in SCOPe 2.06: d3ddqa1, d3ddqa2
  • Chain 'B':
    Compound: Cyclin-A2
    Species: Bos taurus [TaxId:9913]
    Gene: CCNA2, CCNA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3ddqb1, d3ddqb2
  • Chain 'C':
    Compound: Cell division protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CDK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P24941 (1-End)
      • expression tag (0)
    Domains in SCOPe 2.06: d3ddqc1, d3ddqc2
  • Chain 'D':
    Compound: Cyclin-A2
    Species: Bos taurus [TaxId:9913]
    Gene: CCNA2, CCNA
    Database cross-references and differences (RAF-indexed):
    • Uniprot P30274 (0-261)
      • expression tag (262-268)
    Domains in SCOPe 2.06: d3ddqd1, d3ddqd2, d3ddqd3
  • Heterogens: RRC, SGM, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3ddqA (A:)
smenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkeln
hpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafch
shrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgcky
ystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykps
fpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

    Sequence, based on observed residues (ATOM records): (download) 
    >3ddqA (A:)
smenfqkvekigegtygvvykarnkltgevvalkkirldtegvpstaireisllkelnhp
nivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchsh
rvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyys
tavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfp
kwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3ddqB (B:)
svnevpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqne
tlhlavnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkq
vlrmehlvlkvlafdlaaptinqfltqyflhqqpanckveslamflgelslidadpylky
lpsviaaaafhlalytvtgqswpeslvqktgytletlkpclldlhqtylrapqhaqqsir
ekyknskyhgvsllnppetlnvhhhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >3ddqB (B:)
svnevpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqne
tlhlavnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkq
vlrmehlvlkvlafdlaaptinqfltqyflhqqpanckveslamflgelslidadpylky
lpsviaaaafhlalytvtgqswpeslvqktgytletlkpclldlhqtylrapqhaqqsir
ekyknskyhgvsllnppetlnv

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3ddqC (C:)
smenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkeln
hpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafch
shrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgcky
ystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykps
fpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl

    Sequence, based on observed residues (ATOM records): (download) 
    >3ddqC (C:)
smenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkeln
hpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafch
shrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgcky
ystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgvppldedgrsllsqmlhyd
pnkrisakaalahpffqdvtkpvphlr

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >3ddqD (D:)
svnevpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqne
tlhlavnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkq
vlrmehlvlkvlafdlaaptinqfltqyflhqqpanckveslamflgelslidadpylky
lpsviaaaafhlalytvtgqswpeslvqktgytletlkpclldlhqtylrapqhaqqsir
ekyknskyhgvsllnppetlnvhhhhhhh