PDB entry 3d09

View 3d09 on RCSB PDB site
Description: Human p53 core domain with hot spot mutation R249S and second-site suppressor mutations H168R and T123A
Class: transcription
Keywords: p53, Mutant protein, Loop-sheet-helix motif, Acetylation, Activator, Alternative splicing, Anti-oncogene, Apoptosis, Cell cycle, Covalent protein-RNA linkage, Cytoplasm, Disease mutation, DNA-binding, Endoplasmic reticulum, Glycoprotein, Host-virus interaction, Li-Fraumeni syndrome, Metal-binding, Methylation, Nucleus, Phosphoprotein, Polymorphism, Transcription, Transcription regulation, Ubl conjugation, Zinc
Deposited on 2008-05-01, released 2009-01-20
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-01-20, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 1.9 Å
R-factor: 0.207
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Cellular tumor antigen p53
  Species: Homo sapiens [TaxId:9606]
  Gene: TP53
  Database cross-references and differences (RAF-indexed):
  • Uniprot P04637
    • engineered (29)
    • engineered (74)
    • engineered (155)
  Domains in SCOPe 2.06: d3d09a_
• Heterogens: ZN, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence, based on SEQRES records: (download)
  

  >3d09A (A:)
  sssvpsqktyqgsygfrlgflhsgtaksvactyspalnkmfcqlaktcpvqlwvdstppp
  gtrvramaiykqsqrmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfr
  hsvvvpyeppevgsdcttihynymcnsscmggmnrspiltiitledssgnllgrnsfevr
  vcacpgrdrrteeenlrkkg
  

  
  Sequence, based on observed residues (ATOM records): (download)
  

  >3d09A (A:)
  svpsqktyqgsygfrlgflhsvactyspalnkmfcqlaktcpvqlwvdstpppgtrvram
  aiykqsqrmtevvrrcphhercsdglappqhlirvegnlrveylddrntfrhsvvvpyep
  pevgsdcttihynymcnsscmggmnrspiltiitledssgnllgrnsfevrvcacpgrdr
  rteeenlr