PDB entry 3d07

View 3d07 on RCSB PDB site
Description: Human p53 core domain with hot spot mutation R249S (III)
Class: transcription
Keywords: p53, mutant protein, loop-sheet-helix motif, Acetylation, Activator, Alternative splicing, Anti-oncogene, Apoptosis, Cell cycle, Covalent protein-RNA linkage, Cytoplasm, Disease mutation, DNA-binding, Endoplasmic reticulum, Glycoprotein, Host-virus interaction, Li-Fraumeni syndrome, Metal-binding, Methylation, Nucleus, Phosphoprotein, Polymorphism, Transcription, Transcription regulation, Ubl conjugation, Zinc
Deposited on 2008-05-01, released 2009-01-20
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-01-20, with a file datestamp of 2009-02-03.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.168
AEROSPACI score: 0.41 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cellular tumor antigen p53
    Species: Homo sapiens [TaxId:9606]
    Gene: TP53
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04637 (0-End)
      • engineered (155)
    Domains in SCOPe 2.06: d3d07a_
  • Chain 'B':
    Compound: Cellular tumor antigen p53
    Species: Homo sapiens [TaxId:9606]
    Gene: TP53
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04637
      • engineered (155)
    Domains in SCOPe 2.06: d3d07b_
  • Heterogens: ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3d07A (A:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfr
hsvvvpyeppevgsdcttihynymcnsscmggmnrspiltiitledssgnllgrnsfevr
vcacpgrdrrteeenlrkkg

    Sequence, based on observed residues (ATOM records): (download) 
    >3d07A (A:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfr
hsvvvpyeppevgsdcttihynymcnsscmggmrspiltiitledssgnllgrnsfevrv
cacpgrdrrteeen

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3d07B (B:)
sssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstppp
gtrvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfr
hsvvvpyeppevgsdcttihynymcnsscmggmnrspiltiitledssgnllgrnsfevr
vcacpgrdrrteeenlrkkg

    Sequence, based on observed residues (ATOM records): (download) 
    >3d07B (B:)
ssvpsqktyqgsygfrlgflhsgtaksvtctyspalnkmfcqlaktcpvqlwvdstpppg
trvramaiykqsqhmtevvrrcphhercsdsdglappqhlirvegnlrveylddrntfrh
svvvpyeppevgsdcttihynymcnsscmggmnspiltiitledssgnllgrnsfevrvc
acpgrdrrteeenlrkk