PDB entry 3cp6

View 3cp6 on RCSB PDB site
Description: Crystal structure of human farnesyl diphosphate synthase (T201A mutant) complexed with Mg and biphosphonate inhibitor
Class: transferase
Keywords: isoprenoid pathway, cholesterol synthesis, bisphosphonate, structural genomics, structural genomics consortium, sgc, cholesterol biosynthesis, host-virus interaction isoprene biosynthesis, lipid synthesis, steroid biosynthesis, sterol biosynthesis, transferase
Deposited on 2008-03-31, released 2008-04-15
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-10-25, with a file datestamp of 2017-10-20.
Experiment type: XRAY
Resolution: 1.95 Å
R-factor: N/A
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Farnesyl pyrophosphate synthetase
    Species: Homo sapiens [TaxId:9606]
    Gene: FDPS, FPS, KIAA1293
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14324
      • engineered (223)
    Domains in SCOPe 2.07: d3cp6a_
  • Heterogens: MG, RSX, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3cp6A (A:)
mgsshhhhhhssgrenlyfqghmmngdqnsdvyaqekqdfvqhfsqivrvltedemghpe
igdaiarlkevleynaiggkynrgltvvvafrelveprkqdadslqrawtvgwcvellqa
fflvaddimdssltrrgqicwyqkpgvgldaindanlleaciyrllklycreqpyylnli
elflqssyqteigqtldlltapqgnvdlvrftekryksivkykaafysfylpiaaamyma
gidgekehanakkillemgeffqiqddyldlfgdpsvtgkigtdiqdnkcswlvvqclqr
atpeqyqilkenygqkeaekvarvkalyeeldlpavflqyeedsyshimalieqyaaplp
pavflglarkiykrrk

    Sequence, based on observed residues (ATOM records): (download) 
    >3cp6A (A:)
aqekqdfvqhfsqivrvltehpeigdaiarlkevleynaiggkynrgltvvvafrelvep
rkqdadslqrawtvgwcvellqafflvaddimdssltrrgqicwyqkpgvgldaindanl
leaciyrllklycreqpyylnlielflqssyqteigqtldlltapqgnvdlvrftekryk
sivkykaafysfylpiaaamymagidgekehanakkillemgeffqiqddyldlfgdpsv
tgkigtdiqdnkcswlvvqclqratpeqyqilkenygqkeaekvarvkalyeeldlpavf
lqyeedsyshimalieqyaaplppavflglarki