PDB entry 3cow

View 3cow on RCSB PDB site
Description: Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.8 Ang resolution- in complex with sulphonamide inhibitor 2
Class: ligase
Keywords: Mycobacterium tuberculosis, pantothenate biosynthesis, enzymes, ligase, inhibitors, drug design, ATP-binding, Magnesium, Metal-binding, Nucleotide-binding
Deposited on 2008-03-29, released 2008-10-07
The last revision prior to the SCOPe 2.04 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-25.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.162
AEROSPACI score: 0.53 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Pantothenate synthetase
    Species: Mycobacterium tuberculosis
    Gene: panC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0A5R0
      • engineered (77)
    Domains in SCOPe 2.04: d3cowa_
  • Chain 'B':
    Compound: Pantothenate synthetase
    Species: Mycobacterium tuberculosis
    Gene: panC
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0A5R0
      • engineered (2)
    Domains in SCOPe 2.04: d3cowb_
  • Heterogens: 52H, GOL, EOH, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3cowA (A:)
amaipafhpgelnvysapgdvadvsralrltgrrvmlvptmgalheghlalvraakrvpg
svvvvsifvnpmqfgaggdldayprtpdddlaqlraegveiaftpttaamypdglrttvq
pgplaaeleggprpthfagvltvvlkllqivrpdrvffgekdyqqlvlirqlvadfnldv
avvgvptvreadglamssrnryldpaqraaavalsaaltaaahaatagaqaaldaaravl
daapgvavdylelrdiglgpmplngsgrllvaarlgttrlldniaieigtfagtdrpdgy
r

    Sequence, based on observed residues (ATOM records): (download) 
    >3cowA (A:)
ipafhpgelnvysapgdvadvsralrltgrrvmlvptmgalheghlalvraakrvpgsvv
vvsifvnpmqfgaggdldayprtpdddlaqlraegveiaftpttaamypdglrttvqpgp
laaeleggprpthfagvltvvlkllqivrpdrvffgekdyqqlvlirqlvadfnldvavv
gvptvreadglamssrnryldpaqraaavalsaaltaaahaatagaqaaldaaravldaa
pgvavdylelrdiglgpmplngsgrllvaarlgttrlldniaieig

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3cowB (B:)
amaipafhpgelnvysapgdvadvsralrltgrrvmlvptmgalheghlalvraakrvpg
svvvvsifvnpmqfgaggdldayprtpdddlaqlraegveiaftpttaamypdglrttvq
pgplaaeleggprpthfagvltvvlkllqivrpdrvffgekdyqqlvlirqlvadfnldv
avvgvptvreadglamssrnryldpaqraaavalsaaltaaahaatagaqaaldaaravl
daapgvavdylelrdiglgpmplngsgrllvaarlgttrlldniaieigtfagtdrpdgy
r

    Sequence, based on observed residues (ATOM records): (download) 
    >3cowB (B:)
aipafhpgelnvysapgdvadvsralrltgrrvmlvptmgalheghlalvraakrvpgsv
vvvsifvnpmqayprtpdddlaqlraegveiaftpttaamypdglrttvqpgplaaeleg
gprpthfagvltvvlkllqivrpdrvffgekdyqqlvlirqlvadfnldvavvgvptvre
adglamssrnryldpaqraaavalsaaltaaahaatagaqaaldaaravldaapgvavdy
lelrdiglgpmplngsgrllvaarlgttrlldniaieig