PDB entry 3cem

View 3cem on RCSB PDB site
Description: Human glycogen phosphorylase (tense state) in complex with the allosteric inhibitor AVE9423
Class: transferase
Keywords: protein ligand complex, tense state, allosteric inhibitor, Acetylation, Allosteric enzyme, Carbohydrate metabolism, Disease mutation, Glycogen metabolism, Glycogen storage disease, Glycosyltransferase, Nucleotide-binding, Phosphoprotein, Polymorphism, Pyridoxal phosphate
Deposited on 2008-02-29, released 2008-05-27
The last revision prior to the SCOP 1.75 freeze date was dated 2008-06-03, with a file datestamp of 2008-05-30.
Experiment type: XRAY
Resolution: 2.47 Å
R-factor: 0.159
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glycogen phosphorylase, liver form
    Species: HOMO SAPIENS
    Gene: PYGL
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d3cema1
  • Chain 'B':
    Compound: Glycogen phosphorylase, liver form
    Species: HOMO SAPIENS
    Gene: PYGL
    Database cross-references and differences (RAF-indexed): Domains in SCOP 1.75: d3cemb1
  • Heterogens: NBG, PLP, AVD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3cemA (A:)
nvaelkksfnrhlhftlvkdrnvattrdyyfalahtvrdhlvgrwirtqqhyydkcpkrv
yylslefymgrtlqntminlglqnacdeaiyqlgldieeleeieedaglgngglgrlaac
fldsmatlglaaygygiryeygifnqkirdgwqveeaddwlrygnpweksrpefmlpvhf
ygkvehtntgtkwidtqvvlalpydtpvpgymnntvntmrlwsarapndfnlrdfnvgdy
iqavldrnlaenisrvlypndnffegkelrlkqeyfvvaatlqdiirrfkaskfgstrga
gtvfdafpdqvaiqlndthpalaipelmrifvdieklpwskaweltqktfaytnhtvlpe
alerwpvdlvekllprhleiiyeinqkhldrivalfpkdvdrlrrmslieeegskrinma
hlcivgshavngvakihsdivktkvfkdfselepdkfqnktngitprrwlllcnpglael
iaekigedyvkdlsqltklhsflgddvflrelakvkqenklkfsqfleteykvkinpssm
fdvqvkriheykrqllnclhvitmynrikkdpkklfvprtviiggkaapgyhmakmiikl
itsvadvvnndpmvgsklkviflenyrvslaekvipatdlseqistagteasgtgnmkfm
lngaltigtmdganvemaeeageenlfifgmriddvaaldkkgyeakeyyealpelklvi
dqidngffspkqpdlfkdiinmlfyhdrfkvfadyeayvkcqdkvsqlymnpkawntmvl
kniaasgkfssdrtikeyaqniwnvepsd

    Sequence, based on observed residues (ATOM records): (download) 
    >3cemA (A:)
nvaelkksfnrhlhftlvkdrnvattrdyyfalahtvrdhlvgrwirtqqhyydkcpkrv
yylslefymgrtlqntminlglqnacdeaiyqlgldieeleeieedaglgngglgrlaac
fldsmatlglaaygygiryeygifnqkirdgwqveeaddwlrygnpweksrpefmlpvhf
ygkvehtntgtkwidtqvvlalpydtpvpgymnntvntmrlwsarapndfdyiqavldrn
laenisrvlypndnffegkelrlkqeyfvvaatlqdiirrfkaskftvfdafpdqvaiql
ndthpalaipelmrifvdieklpwskaweltqktfaytnhtvlpealerwpvdlvekllp
rhleiiyeinqkhldrivalfpkdvdrlrrmslieeegskrinmahlcivgshavngvak
ihsdivktkvfkdfselepdkfqnktngitprrwlllcnpglaeliaekigedyvkdlsq
ltklhsflgddvflrelakvkqenklkfsqfleteykvkinpssmfdvqvkriheykrql
lnclhvitmynrikkdpkklfvprtviiggkaapgyhmakmiiklitsvadvvnndpmvg
sklkviflenyrvslaekvipatdlseqistagteasgtgnmkfmlngaltigtmdganv
emaeeageenlfifgmriddvaaldkkgyeakeyyealpelklvidqidngffspkqpdl
fkdiinmlfyhdrfkvfadyeayvkcqdkvsqlymnpkawntmvlkniaasgkfssdrti
keyaqniwnvepsd

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3cemB (B:)
nvaelkksfnrhlhftlvkdrnvattrdyyfalahtvrdhlvgrwirtqqhyydkcpkrv
yylslefymgrtlqntminlglqnacdeaiyqlgldieeleeieedaglgngglgrlaac
fldsmatlglaaygygiryeygifnqkirdgwqveeaddwlrygnpweksrpefmlpvhf
ygkvehtntgtkwidtqvvlalpydtpvpgymnntvntmrlwsarapndfnlrdfnvgdy
iqavldrnlaenisrvlypndnffegkelrlkqeyfvvaatlqdiirrfkaskfgstrga
gtvfdafpdqvaiqlndthpalaipelmrifvdieklpwskaweltqktfaytnhtvlpe
alerwpvdlvekllprhleiiyeinqkhldrivalfpkdvdrlrrmslieeegskrinma
hlcivgshavngvakihsdivktkvfkdfselepdkfqnktngitprrwlllcnpglael
iaekigedyvkdlsqltklhsflgddvflrelakvkqenklkfsqfleteykvkinpssm
fdvqvkriheykrqllnclhvitmynrikkdpkklfvprtviiggkaapgyhmakmiikl
itsvadvvnndpmvgsklkviflenyrvslaekvipatdlseqistagteasgtgnmkfm
lngaltigtmdganvemaeeageenlfifgmriddvaaldkkgyeakeyyealpelklvi
dqidngffspkqpdlfkdiinmlfyhdrfkvfadyeayvkcqdkvsqlymnpkawntmvl
kniaasgkfssdrtikeyaqniwnvepsd

    Sequence, based on observed residues (ATOM records): (download) 
    >3cemB (B:)
nvaelkksfnrhlhftlvkdrnvattrdyyfalahtvrdhlvgrwirtqqhyydkcpkrv
yylslefymgrtlqntminlglqnacdeaiyqlgldieeleeieedaglgngglgrlaac
fldsmatlglaaygygiryeygifnqkirdgwqveeaddwlrygnpweksrpefmlpvhf
ygkvehtntgtkwidtqvvlalpydtpvpgymnntvntmrlwsarapndfdyiqavldrn
laenisrvlypndnffegkelrlkqeyfvvaatlqdiirrfkaskftvfdafpdqvaiql
ndthpalaipelmrifvdieklpwskaweltqktfaytnhtvlpealerwpvdlvekllp
rhleiiyeinqkhldrivalfpkdvdrlrrmslieeegskrinmahlcivgshavngvak
ihsdivktkvfkdfselepdkfqnktngitprrwlllcnpglaeliaekigedyvkdlsq
ltklhsflgddvflrelakvkqenklkfsqfleteykvkinpssmfdvqvkriheykrql
lnclhvitmynrikkdpkklfvprtviiggkaapgyhmakmiiklitsvadvvnndpmvg
sklkviflenyrvslaekvipatdlseqistagteasgtgnmkfmlngaltigtmdganv
emaeeageenlfifgmriddvaaldkkgyeakeyyealpelklvidqidngffspkqpdl
fkdiinmlfyhdrfkvfadyeayvkcqdkvsqlymnpkawntmvlkniaasgkfssdrti
keyaqniwnvepsd