PDB entry 3bhu

View 3bhu on RCSB PDB site
Description: Structure of phosphorylated Thr160 CDK2/cyclin A in complex with the inhibitor meriolin 5
Class: transferase
Keywords: Ser/Thr protein kinase, transferase, phosphorylation, cell cycle, ATP-binding, Cell division, Mitosis, Nucleotide-binding, Phosphoprotein, Serine/threonine-protein kinase, Cyclin
Deposited on 2007-11-29, released 2008-02-12
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-10-25, with a file datestamp of 2017-10-20.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.25 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Cell division protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CDK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P24941 (2-299)
      • expression tag (0-1)
    Domains in SCOPe 2.07: d3bhua1, d3bhua2
  • Chain 'B':
    Compound: Cyclin-A2
    Species: Bos taurus [TaxId:9913]
    Gene: CCNA2, CCNA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3bhub1, d3bhub2
  • Chain 'C':
    Compound: Cell division protein kinase 2
    Species: Homo sapiens [TaxId:9606]
    Gene: CDK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P24941 (2-End)
      • expression tag (0-1)
    Domains in SCOPe 2.07: d3bhuc1, d3bhuc2
  • Chain 'D':
    Compound: Cyclin-A2
    Species: Bos taurus [TaxId:9913]
    Gene: CCNA2, CCNA
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d3bhud1, d3bhud2
  • Heterogens: MHR, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >3bhuA (A:)
    gsmenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkel
    nhpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafc
    hshrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgck
    yystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykp
    sfpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl
    

    Sequence, based on observed residues (ATOM records): (download)
    >3bhuA (A:)
    gsmenfqkvekigegtygvvykarnkltgevvalkkirldtegvpstaireisllkelnh
    pnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafchs
    hrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyy
    stavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsf
    pkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3bhuB (B:)
    svnevpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqne
    tlhlavnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkq
    vlrmehlvlkvlafdlaaptinqfltqyflhqqpanckveslamflgelslidadpylky
    lpsviaaaafhlalytvtgqswpeslvqktgytletlkpclldlhqtylrapqhaqqsir
    ekyknskyhgvsllnppetlnv
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >3bhuC (C:)
    gsmenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkel
    nhpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafc
    hshrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgck
    yystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykp
    sfpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlrl
    

    Sequence, based on observed residues (ATOM records): (download)
    >3bhuC (C:)
    gsmenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllkel
    nhpnivklldvihtenklylvfeflhqdlkkfmdasaltgiplpliksylfqllqglafc
    hshrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgck
    yystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtfskvvppldedgrslls
    qmlhydpnkrisakaalahpffqdvtkpvphl
    

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download)
    >3bhuD (D:)
    svnevpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqne
    tlhlavnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkq
    vlrmehlvlkvlafdlaaptinqfltqyflhqqpanckveslamflgelslidadpylky
    lpsviaaaafhlalytvtgqswpeslvqktgytletlkpclldlhqtylrapqhaqqsir
    ekyknskyhgvsllnppetlnv