PDB entry 3b7w

View 3b7w on RCSB PDB site
Description: Crystal structure of human acyl-CoA synthetase medium-chain family member 2A, with L64P mutation
Class: ligase
Keywords: Middle-chain acyl-CoA synthetase, Xenobiotic/medium-chain fatty acid-CoA ligase, Structural Genomics Consortium, SGC, ATP-binding, Fatty acid metabolism, Lipid metabolism, Magnesium, Metal-binding, Mitochondrion, Nucleotide-binding, Transit peptide, LIGASE
Deposited on 2007-10-31, released 2007-11-27
The last revision prior to the SCOPe 2.06 freeze date was dated 2011-07-13, with a file datestamp of 2011-05-08.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.171
AEROSPACI score: 0.48 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Acyl-coenzyme A synthetase ACSM2A, mitochondrial precursor
    Species: Homo sapiens [TaxId:9606]
    Gene: ACSM2A, ACSM2, MACS2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q08AH3
      • engineered (56)
    Domains in SCOPe 2.06: d3b7wa_
  • Heterogens: MG, CL, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3b7wA (A:)
mghhhhhhssgvdlgtenlyfqsmslqwghqevpakfnfasdvldhwadmekagkrppsp
alwwvngkgkelmwnfrelsensqqaanvlsgacglqrgdrvavvlprvpewwlvilgci
raglifmpgtiqmkstdilyrlqmskakaivagdeviqevdtvasecpslrikllvseks
cdgwlnfkkllneastthhcvetgsqeasaiyftsgtsglpkmaehsysslglkakmdag
wtglqasdimwtisdtgwilnilcslmepwalgactfvhllpkfdplvilktlssypiks
mmgapivyrmllqqdlssykfphlqncvtvgesllpetlenwraqtgldiresygqtetg
ltcmvsktmkikpgymgtaascydvqiiddkgnvlppgtegdigirvkpirpigifsgyv
dnpdktaanirgdfwllgdrgikdedgyfqfmgraddiinssgyrigpsevenalmehpa
vvetavisspdpvrgevvkafvvlasqflshdpeqltkelqqhvksvtapykyprkiefv
lnlpktvtgkiqraklrdkewkmsgkaraq

    Sequence, based on observed residues (ATOM records): (download) 
    >3b7wA (A:)
lqwghqevpakfnfasdvldhwadmekagkrppspalwwvngkgkelmwnfrelsensqq
aanvlsgacglqrgdrvavvlprvpewwlvilgciraglifmpgtiqmkstdilyrlqms
kakaivagdeviqevdtvasecpslrikllvsekscdgwlnfkkllneastthhcvetgs
qeasaiyftsgtsglpkmaehsysslglkakmdagwtglqasdimwtisdtgwilnilcs
lmepwalgactfvhllpkfdplvilktlssypiksmmgapivyrmllqqdlssykfphlq
ncvtvgesllpetlenwraqtgldiresygqtetgltcmvsktmkikpgymgtaascydv
qiiddkgnvlppgtegdigirvkpirpigifsgyvdnpdktaanirgdfwllgdrgikde
dgyfqfmgraddiinssgyrigpsevenalmehpavvetavisspdpvrgevvkafvvla
sqflshdpeqltkelqqhvksvtapykyprkiefvlnlpktvtgkiqraklrdkewk