PDB entry 3am5

View 3am5 on RCSB PDB site
Description: K316A mutant of Enoyl-ACP Reductase from Plasmodium falciparum (PfENR) in complex with triclosan
Class: oxidoreductase/oxidoreductase inhibitor
Keywords: Triclosan, Enoyl-ACP reductase, mutant, oxidoreductase, P.falciparum, FabI, OXIDOREDUCTASE-OXIDOREDUCTASE INHIBITOR complex
Deposited on 2010-08-14, released 2011-03-16
The last revision prior to the SCOPe 2.04 freeze date was dated 2011-03-16, with a file datestamp of 2011-03-11.
Experiment type: XRAY
Resolution: 2.05 Å
R-factor: 0.166
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Enoyl-ACP reductase
    Species: Plasmodium falciparum [TaxId:5833]
    Gene: FabI
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9BJJ9 (Start-328)
      • engineered mutation (220)
    Domains in SCOPe 2.04: d3am5a_
  • Chain 'B':
    Compound: Enoyl-ACP reductase
    Species: Plasmodium falciparum [TaxId:5833]
    Gene: FabI
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9BJJ9 (0-328)
      • engineered mutation (220)
    Domains in SCOPe 2.04: d3am5b_
  • Heterogens: NAD, TCL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3am5A (A:)
nedicfiagigdtngygwgiakelskrnvkiifgiwppvynifmknykngkfdndmiidk
dkkmnildmlpfdasfdtandideetknnkrynmlqnytiedvanlihqkygkinmlvhs
lanakevqkdllntsrkgyldalskssyslislckyfvnimkpqssiisltyhasqkvvp
gygggmssakaalesdtrvlayhlgrnynirintisagplasraatainklnntyenntn
qnknrnrhdvhnimnnsgekeekkisasqnytfidyaieysekyaplrqkllstdigsva
sfllsresraitgqtiyvdnglnimflpd

    Sequence, based on observed residues (ATOM records): (download) 
    >3am5A (A:)
edicfiagigdtngygwgiakelskrnvkiifgiwppvynifmknykngkfdndmiidkd
kkmnildmlpfdasfdtandideetknnkrynmlqnytiedvanlihqkygkinmlvhsl
anakevqkdllntsrkgyldalskssyslislckyfvnimkpqssiisltyhasqkvvpg
ygggmssakaalesdtrvlayhlgrnynirintisagplasraataintfidyaieysek
yaplrqkllstdigsvasfllsresraitgqtiyvdnglnimflpd

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3am5B (B:)
nedicfiagigdtngygwgiakelskrnvkiifgiwppvynifmknykngkfdndmiidk
dkkmnildmlpfdasfdtandideetknnkrynmlqnytiedvanlihqkygkinmlvhs
lanakevqkdllntsrkgyldalskssyslislckyfvnimkpqssiisltyhasqkvvp
gygggmssakaalesdtrvlayhlgrnynirintisagplasraatainklnntyenntn
qnknrnrhdvhnimnnsgekeekkisasqnytfidyaieysekyaplrqkllstdigsva
sfllsresraitgqtiyvdnglnimflpd

    Sequence, based on observed residues (ATOM records): (download) 
    >3am5B (B:)
nedicfiagigdtngygwgiakelskrnvkiifgiwppvynifmknykngkfdndmiidk
dkkmnildmlpfdasfdtandideetknnkrynmlqnytiedvanlihqkygkinmlvhs
lanakevqkdllntsrkgyldalskssyslislckyfvnimkpqssiisltyhasqkvvp
gygggmssakaalesdtrvlayhlgrnynirintisagplasraatainytfidyaieys
ekyaplrqkllstdigsvasfllsresraitgqtiyvdnglnimflpd