PDB entry 3a29

View 3a29 on RCSB PDB site
Description: Crystal structure of human liver FBPase in complex with tricyclic inhibitor
Class: hydrolase
Keywords: HYDROLASE, Allosteric enzyme, Carbohydrate metabolism, Disease mutation, Gluconeogenesis, Magnesium, Metal-binding, Polymorphism
Deposited on 2009-05-08, released 2009-10-06
The last revision prior to the SCOPe 2.06 freeze date was dated 2009-10-06, with a file datestamp of 2009-10-02.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.208
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Fructose-1,6-bisphosphatase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: FBP1, FBP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3a29a_
  • Chain 'B':
    Compound: Fructose-1,6-bisphosphatase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: FBP1, FBP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3a29b_
  • Chain 'C':
    Compound: Fructose-1,6-bisphosphatase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: FBP1, FBP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3a29c_
  • Chain 'D':
    Compound: Fructose-1,6-bisphosphatase 1
    Species: Homo sapiens [TaxId:9606]
    Gene: FBP1, FBP
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d3a29d_
  • Heterogens: 2T0, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >3a29A (A:)
adqapfdtdvntltrfvmeegrkargtgeltqllnslctavkaissavrkagiahlygia
gstnvtgdqvkkldvlsndlvmnmlkssfatcvlvseedkhaiivepekrgkyvvcfdpl
dgssnidclvsvgtifgiyrkkstdepsekdalqpgrnlvaagyalygsatmlvlamdcg
vncfmldpaigefilvdkdvkikkkgkiyslnegyakdfdpavteyiqrkkfppdnsapy
garyvgsmvadvhrtlvyggiflypankkspngklrllyecnpmayvmekaggmattgke
avldviptdihqrapvilgspddvleflkvyekhsaq

    Sequence, based on observed residues (ATOM records): (download) 
    >3a29A (A:)
dvntltrfvmeegrkargtgeltqllnslctavkaissavrkagiahlygiagvkkldvl
sndlvmnmlkssfatcvlvseedkhaiivepekrgkyvvcfdpldgssnidclvsvgtif
giyrkkstdepsekdalqpgrnlvaagyalygsatmlvlamdcgvncfmldpaigefilv
dkdvkikkkgkiyslnegyakdfdpavteyiqrkkfppdnsapygaryvgsmvadvhrtl
vyggiflypankkspngklrllyecnpmayvmekaggmattgkeavldviptdihqrapv
ilgspddvleflkvyekhs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >3a29B (B:)
adqapfdtdvntltrfvmeegrkargtgeltqllnslctavkaissavrkagiahlygia
gstnvtgdqvkkldvlsndlvmnmlkssfatcvlvseedkhaiivepekrgkyvvcfdpl
dgssnidclvsvgtifgiyrkkstdepsekdalqpgrnlvaagyalygsatmlvlamdcg
vncfmldpaigefilvdkdvkikkkgkiyslnegyakdfdpavteyiqrkkfppdnsapy
garyvgsmvadvhrtlvyggiflypankkspngklrllyecnpmayvmekaggmattgke
avldviptdihqrapvilgspddvleflkvyekhsaq

    Sequence, based on observed residues (ATOM records): (download) 
    >3a29B (B:)
dvntltrfvmeegrkargtgeltqllnslctavkaissavrkagiahlygiagkkldvls
ndlvmnmlkssfatcvlvseedkhaiivepekrgkyvvcfdpldgssnidclvsvgtifg
iyrkkstdepsekdalqpgrnlvaagyalygsatmlvlamdcgvncfmldpaigefilvd
kdvkikkkgkiyslnegyakdfdpavteyiqrkkfppdnsapygaryvgsmvadvhrtlv
yggiflypankkspngklrllyecnpmayvmekaggmattgkeavldviptdihqrapvi
lgspddvleflkvyekhs

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >3a29C (C:)
adqapfdtdvntltrfvmeegrkargtgeltqllnslctavkaissavrkagiahlygia
gstnvtgdqvkkldvlsndlvmnmlkssfatcvlvseedkhaiivepekrgkyvvcfdpl
dgssnidclvsvgtifgiyrkkstdepsekdalqpgrnlvaagyalygsatmlvlamdcg
vncfmldpaigefilvdkdvkikkkgkiyslnegyakdfdpavteyiqrkkfppdnsapy
garyvgsmvadvhrtlvyggiflypankkspngklrllyecnpmayvmekaggmattgke
avldviptdihqrapvilgspddvleflkvyekhsaq

    Sequence, based on observed residues (ATOM records): (download) 
    >3a29C (C:)
dvntltrfvmeegrkargtgeltqllnslctavkaissavrkagiahlygiagkkldvls
ndlvmnmlkssfatcvlvseedkhaiivepekrgkyvvcfdpldgssnidclvsvgtifg
iyrkkstdepsekdalqpgrnlvaagyalygsatmlvlamdcgvncfmldpaigefilvd
kdvkikkkgkiyslnegyakdfdpavteyiqrkkfppdnsapygaryvgsmvadvhrtlv
yggiflypankkspngklrllyecnpmayvmekaggmattgkeavldviptdihqrapvi
lgspddvleflkvyekhs

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >3a29D (D:)
adqapfdtdvntltrfvmeegrkargtgeltqllnslctavkaissavrkagiahlygia
gstnvtgdqvkkldvlsndlvmnmlkssfatcvlvseedkhaiivepekrgkyvvcfdpl
dgssnidclvsvgtifgiyrkkstdepsekdalqpgrnlvaagyalygsatmlvlamdcg
vncfmldpaigefilvdkdvkikkkgkiyslnegyakdfdpavteyiqrkkfppdnsapy
garyvgsmvadvhrtlvyggiflypankkspngklrllyecnpmayvmekaggmattgke
avldviptdihqrapvilgspddvleflkvyekhsaq

    Sequence, based on observed residues (ATOM records): (download) 
    >3a29D (D:)
dvntltrfvmeegrkargtgeltqllnslctavkaissavrkagiahlygiagkkldvls
ndlvmnmlkssfatcvlvseedkhaiivepekrgkyvvcfdpldgssnidclvsvgtifg
iyrkkstdepsekdalqpgrnlvaagyalygsatmlvlamdcgvncfmldpaigefilvd
kdvkikkkgkiyslnegyakdfdpavteyiqrkkfppdnsapygaryvgsmvadvhrtlv
yggiflypankkspngklrllyecnpmayvmekaggmattgkeavldviptdihqrapvi
lgspddvleflkvyekhs