PDB entry 2ycr

View 2ycr on RCSB PDB site
Description: crystal structure of checkpoint kinase 2 in complex with inhibitor pv976
Class: transferase
Keywords: transferase, anticancer drug design
Deposited on 2011-03-16, released 2011-11-16
The last revision prior to the SCOPe 2.07 freeze date was dated 2011-11-16, with a file datestamp of 2011-11-11.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.20206
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: serine/threonine-protein kinase chk2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot O96017
      • conflict (299)
    Domains in SCOPe 2.07: d2ycra_
  • Heterogens: HCW, NO3, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >2ycrA (A:)
msvypkalrdeyimsktlgsgacgevklaferktckkvaikiiskrkfaigsareadpal
nveteieilkklnhpciikiknffdaedyyivlelmeggelfdkvvgnkrlkeatcklyf
yqmllavqylhengiihrdlkpenvllssqeedclikitdfghskilgetslmrtlcgtp
tylapevlvsvgtagynravdcwslgvilficlsgyppfsehrtqvslkdqitsgkynfi
pevwaevsekaldlvkkllvvdpkarftteealrhpwlqdedmkrkfqdllseenestak
pqvlaqpstsrkrpregeaegae

    Sequence, based on observed residues (ATOM records): (download) 
    >2ycrA (A:)
vypkalrdeyimsktlgsgevklaferktckkvaikiisknveteieilkklnhpciiki
knffdaedyyivlelmeggelfdkvvgnkrlkeatcklyfyqmllavqylhengiihrdl
kpenvllssqeedclikitdfghskilgetslmrtlcgtptylapevlvsvgtagynrav
dcwslgvilficlsgyppfsehrtqvslkdqitsgkynfipevwaevsekaldlvkkllv
vdpkarftteealrhpwlqdedmkrkfqdllseenestakpq