PDB entry 2yc0
View 2yc0 on RCSB PDB site
Description: factor inhibiting hif-1 alpha in complex with r-2-hydroxyglutarate
Class: oxidoreductase
Keywords: oxidoreductase, dioxygenase, metal-binding, transcription, helix-loop-helix-beta, dsbh, facial triad, asparaginyl/aspartyl hydroxylase, transcription and epigenetic regulation, signaling, development, cell structure, ankyrin repeat domain, ard, beta-hydroxylation, transcription activator/inhibitor, phosphorylation, s-nitrosylation
Deposited on
2011-03-10, released
2011-03-30
The last revision prior to the SCOPe 2.04 freeze date was dated
2011-05-11, with a file datestamp of
2011-05-06.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: 0.241
AEROSPACI score: 0.37
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Hypoxia-inducible factor 1-alpha inhibitor
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.04: d2yc0a_ - Heterogens: FE2, 2HG, GOL, SO4, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2yc0A (A:)
gshmaataaeavasgsgepreeagalgpawdesqlrsysfptrpiprlsqsdpraeelie
neepvvltdtnlvypalkwdleylqenigngdfsvysasthkflyydekkmanfqnfkpr
snreemkfhefveklqdiqqrggeerlylqqtlndtvgrkivmdflgfnwnwinkqqgkr
gwgqltsnllligmegnvtpahydeqqnffaqikgykrcilfppdqfeclypypvhhpcd
rqsqvdfdnpdyerfpnfqnvvgyetvvgpgdvlyipmywwhhiesllnggititvnfwy
kgaptpkrieyplkahqkvaimrniekmlgealgnpqevgpllntmikgryn
Sequence, based on observed residues (ATOM records): (download)
>2yc0A (A:)
maataaeavasgsgepreeagalgpawdesqlrsysfptrpiprlsqsdpraeelienee
pvvltdtnlvypalkwdleylqenigngdfsvysasthkflyydekkmanfqnfkprsnr
eemkfhefveklqdiqqrggeerlylqqtlndtvgrkivmdflgfnwnwinkqqgkrgwg
qltsnllligmegnvtpahydeqqnffaqikgykrcilfppdqfeclypypvhhpcdrqs
qvdfdnpdyerfpnfqnvvgyetvvgpgdvlyipmywwhhiesllnggititvnfwykga
ptpkrieyplkahqkvaimrniekmlgealgnpqevgpllntmikgryn