PDB entry 2y8l
View 2y8l on RCSB PDB site
Description: Structure of an active form of mammalian AMPK in complex with two ADP
Class: transferase
Keywords: transferase, nucleotide-binding, serine/threonine-protein kinase
Deposited on
2011-02-07, released
2011-03-16
The last revision prior to the SCOPe 2.07 freeze date was dated
2014-01-22, with a file datestamp of
2014-01-17.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.229
AEROSPACI score: 0.22
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: 5'-amp-activated protein kinase catalytic subunit alpha-1
Species: Rattus norvegicus [TaxId:10116]
Database cross-references and differences (RAF-indexed):
- Uniprot P54645 (18-166)
- cloning artifact (15-17)
- cloning artifact (167-172)
Domains in SCOPe 2.07: d2y8la1, d2y8la2, d2y8la3 - Chain 'B':
Compound: 5'-amp-activated protein kinase subunit beta-2
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d2y8lb_ - Chain 'E':
Compound: 5'-amp-activated protein kinase subunit gamma-1
Species: Rattus norvegicus [TaxId:10116]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.07: d2y8le1, d2y8le2 - Heterogens: ADP, AMP, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>2y8lA (A:)
mshhhhhhsglvprgsmawhlgirsqsrpndimaevcraikqldyewkvvnpyylrvrrk
npvtstfskmslqlyqvdsrtylldfrsiddeiteaksgtatpqrsgsisnyrscqrsds
daeaqgkpsevsltssvtsldsspvdvaprpgshtieffemcanliknsctvn
Sequence, based on observed residues (ATOM records): (download)
>2y8lA (A:)
smawhlgirsqsrpndimaevcraikqldyewkvvnpyylrvrrknpvtstfskmslqly
qvdsrtylldfrsiddevaprpgshtieffemcanliknsctvn
- Chain 'B':
Sequence, based on SEQRES records: (download)
>2y8lB (B:)
mgpygqemyafrseerfksppilpphllqvilnkdtniscdpallpepnhvmlnhlyals
ikdsvmvlsathrykkkyvttllykpi
Sequence, based on observed residues (ATOM records): (download)
>2y8lB (B:)
gqemyafrseerfksppilpphllqvilnpnhvmlnhlyalsikdsvmvlsathrykkky
vttllykpi
- Chain 'E':
Sequence, based on SEQRES records: (download)
>2y8lE (E:)
mesvaaesapapenehsqetpesnssvyttfmkshrcydliptssklvvfdtslqvkkaf
falvtngvraaplwdskkqsfvgmltitdfinilhryyksalvqiyeleehkietwrevy
lqdsfkplvcispnaslfdavsslirnkihrlpvidpesgntlyilthkrilkflklfit
efpkpefmsksleelqigtyaniamvrtttpvyvalgifvqhrvsalpvvdekgrvvdiy
skfdvinlaaektynnldvsvtkalqhrshyfegvlkcylhetleaiinrlveaevhrlv
vvdehdvvkgivslsdilqalvltggekkp
Sequence, based on observed residues (ATOM records): (download)
>2y8lE (E:)
snssvyttfmkshrcydliptssklvvfdtslqvkkaffalvtngvraaplwdskkqsfv
gmltitdfinilhryyksalvqiyeleehkietwrevylqdsfkplvcispnaslfdavs
slirnkihrlpvidpesgntlyilthkrilkflklfitefpkpefmsksleelqigtyan
iamvrtttpvyvalgifvqhrvsalpvvdekgrvvdiyskfdvinlaaektynnldvsvt
kalqhrshyfegvlkcylhetleaiinrlveaevhrlvvvdehdvvkgivslsdilqalv
ltgge