PDB entry 2x5o

View 2x5o on RCSB PDB site
Description: discovery of novel 5-benzylidenerhodanine- and 5-benzylidene-thiazolidine-2,4-dione inhibitors of murd ligase
Class: ligase
Keywords: ATP-binding, cell cycle, cell division, cell shape, cell wall biogenesis/degradation, ligase, peptidoglycan synthesis
Deposited on 2010-02-10, released 2010-09-15
The last revision prior to the SCOPe 2.04 freeze date was dated 2011-08-31, with a file datestamp of 2011-08-26.
Experiment type: XRAY
Resolution: 1.46 Å
R-factor: 0.1868
AEROSPACI score: 0.65 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: udp-n-acetylmuramoylalanine--d-glutamate ligase
    Species: ESCHERICHIA COLI [TaxId:668369]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P14900 (0-436)
      • expression tag (437-438)
    Domains in SCOPe 2.04: d2x5oa1, d2x5oa2, d2x5oa3
  • Heterogens: VSV, AZI, SO4, SO3, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >2x5oA (A:)
adyqgknvviiglgltglscvdfflargvtprvmdtrmtppgldklpeaverhtgslnde
wlmaadlivaspgialahpslsaaadagieivgdielfcreaqapivaitgsngkstvtt
lvgemakaagvnvgvggniglpalmllddecelyvlelssfqlettsslqavaatilnvt
edhmdrypfglqqyraaklriyenakvcvvnaddaltmpirgadercvsfgvnmgdyhln
hqqgetwlrvkgekvlnvkemklsgqhnytnalaalaladaaglprasslkalttftglp
hrfevvlehngvrwindskatnvgsteaalnglhvdgtlhlllggdgksadfsplaryln
gdnvrlycfgrdgaqlaalrpevaeqtetmeqamrllaprvqpgdmvllspacasldqfk
nfeqrgnefarlakelgsh